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In vivo spontaneous Ca2+ activity in the pre-hearing mammalian cochlea

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  • Francesca Faveri

    (University of Sheffield)

  • Federico Ceriani

    (University of Sheffield)

  • Walter Marcotti

    (University of Sheffield
    University of Sheffield)

Abstract

The refinement of neural circuits towards mature function is driven during development by patterned spontaneous calcium-dependent electrical activity. In the auditory system, this sensory-independent activity arises in the pre-hearing cochlea and regulates the survival and refinement of the auditory pathway. However, the origin and interplay of calcium signals during cochlear development is unknown in vivo. Here we show how calcium dynamics in the cochlear neuroepithelium of live pre-hearing mice shape the activity of the inner hair cells (IHCs) and their afferent synapses. Both IHCs and supporting cells (SCs) generate spontaneous calcium-dependent activity. Calcium waves from SCs synchronise the activity of nearby IHCs, which then spreads longitudinally recruiting several additional IHCs via a calcium wave-independent mechanism. This synchronised IHC activity in vivo increases the probability of afferent terminal recruitment. Moreover, the modiolar-to-pillar segregation in sound sensitivity of mature auditory nerve fibres appears to be primed at pre-hearing ages.

Suggested Citation

  • Francesca Faveri & Federico Ceriani & Walter Marcotti, 2025. "In vivo spontaneous Ca2+ activity in the pre-hearing mammalian cochlea," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55519-w
    DOI: 10.1038/s41467-024-55519-w
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    1. Yixiang Wang & Maya Sanghvi & Alexandra Gribizis & Yueyi Zhang & Lei Song & Barbara Morley & Daniel G. Barson & Joseph Santos-Sacchi & Dhasakumar Navaratnam & Michael Crair, 2021. "Efferent feedback controls bilateral auditory spontaneous activity," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    2. Nicolas X. Tritsch & Eunyoung Yi & Jonathan E. Gale & Elisabeth Glowatzki & Dwight E. Bergles, 2007. "The origin of spontaneous activity in the developing auditory system," Nature, Nature, vol. 450(7166), pages 50-55, November.
    3. Laura F. Corns & Stuart L. Johnson & Terri Roberts & Kishani M. Ranatunga & Aenea Hendry & Federico Ceriani & Saaid Safieddine & Karen P. Steel & Andy Forge & Christine Petit & David N. Furness & Corn, 2018. "Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    4. Corné J. Kros & J. Peter Ruppersberg & Alfons Rüsch, 1998. "Expression of a potassium current in inner hair cells during development of hearing in mice," Nature, Nature, vol. 394(6690), pages 281-284, July.
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