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Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling

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  • Raquel Francés

    (Energy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research University)

  • Yasmine Rabah

    (Energy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research University)

  • Thomas Preat

    (Energy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research University)

  • Pierre-Yves Plaçais

    (Energy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research University)

Abstract

An essential role of glial cells is to comply with the large and fluctuating energy needs of neurons. Metabolic adaptation is integral to the acute stress response, suggesting that glial cells could be major, yet overlooked, targets of stress hormones. Here we show that Dh44 neuropeptide, Drosophila homologue of mammalian corticotropin-releasing hormone (CRH), acts as an experience-dependent metabolic switch for glycolytic output in glia. Dh44 released by dopamine neurons limits glial fatty acid synthesis and build-up of lipid stores. Although basally active, this hormonal axis is acutely stimulated following learning of a danger-predictive cue. This results in transient suppression of glial anabolic use of pyruvate, sparing it for memory-relevant energy supply to neurons. Diverting pyruvate destination may dampen the need to upregulate glial glycolysis in response to increased neuronal demand. Although beneficial for the energy efficiency of memory formation, this mechanism reveals an ongoing competition between neuronal fuelling and glial anabolism.

Suggested Citation

  • Raquel Francés & Yasmine Rabah & Thomas Preat & Pierre-Yves Plaçais, 2024. "Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54778-x
    DOI: 10.1038/s41467-024-54778-x
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    1. Dafni Hadjieconomou & George King & Pedro Gaspar & Alessandro Mineo & Laura Blackie & Tomotsune Ameku & Chris Studd & Alex Mendoza & Fengqiu Diao & Benjamin H. White & André E. X. Brown & Pierre-Yves , 2020. "Enteric neurons increase maternal food intake during reproduction," Nature, Nature, vol. 587(7834), pages 455-459, November.
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