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Population genomics of Plasmodium ovale species in sub-Saharan Africa

Author

Listed:
  • Kelly Carey-Ewend

    (University of North Carolina)

  • Zachary R. Popkin-Hall

    (University of North Carolina)

  • Alfred Simkin

    (Brown University)

  • Meredith Muller

    (University of North Carolina)

  • Chris Hennelly

    (University of North Carolina)

  • Wenqiao He

    (University of North Carolina)

  • Kara A. Moser

    (University of North Carolina)

  • Claudia Gaither

    (University of North Carolina)

  • Karamoko Niaré

    (Brown University)

  • Farhang Aghakanian

    (University of North Carolina)

  • Sindew Feleke

    (Ethiopian Public Health Institute)

  • Bokretsion G. Brhane

    (Ethiopian Public Health Institute)

  • Fernandine Phanzu

    (SANRU Asbl)

  • Melchior Mwandagalirwa Kashamuka

    (Kinshasa School of Public Health)

  • Ozkan Aydemir

    (University of Massachusetts)

  • Colin J. Sutherland

    (London School of Hygiene and Tropical Medicine)

  • Deus S. Ishengoma

    (National Institute for Medical Research (NIMR)
    Kampala International University in Tanzania)

  • Innocent M. Ali

    (University of Dschang)

  • Billy Ngasala

    (Muhimbili University of Health and Allied Sciences)

  • Albert Kalonji

    (SANRU Asbl)

  • Antoinette Tshefu

    (Kinshasa School of Public Health)

  • Jonathan B. Parr

    (University of North Carolina
    University of North Carolina
    University of North Carolina)

  • Jeffrey A. Bailey

    (Brown University)

  • Jonathan J. Juliano

    (University of North Carolina
    University of North Carolina
    University of North Carolina
    University of North Carolina)

  • Jessica T. Lin

    (University of North Carolina
    University of North Carolina
    University of North Carolina)

Abstract

Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we present a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates are predominantly monoclonal (43/45), with their genetic similarity aligning with geography. Pow shows lower average nucleotide diversity (1.8×10−4) across the genome compared to Poc (3.0×10−4) (p

Suggested Citation

  • Kelly Carey-Ewend & Zachary R. Popkin-Hall & Alfred Simkin & Meredith Muller & Chris Hennelly & Wenqiao He & Kara A. Moser & Claudia Gaither & Karamoko Niaré & Farhang Aghakanian & Sindew Feleke & Bok, 2024. "Population genomics of Plasmodium ovale species in sub-Saharan Africa," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54667-3
    DOI: 10.1038/s41467-024-54667-3
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    References listed on IDEAS

    as
    1. Sasha V. Siegel & Hidayat Trimarsanto & Roberto Amato & Kathryn Murie & Aimee R. Taylor & Edwin Sutanto & Mariana Kleinecke & Georgia Whitton & James A. Watson & Mallika Imwong & Ashenafi Assefa & Awa, 2024. "Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. A. R. Gomes & A. Marin-Menendez & S. H. Adjalley & C. Bardy & C. Cassan & M. C. S. Lee & A. M. Talman, 2022. "A transcriptional switch controls sex determination in Plasmodium falciparum," Nature, Nature, vol. 612(7940), pages 528-533, December.
    3. Gavin G. Rutledge & Ulrike Böhme & Mandy Sanders & Adam J. Reid & James A. Cotton & Oumou Maiga-Ascofare & Abdoulaye A. Djimdé & Tobias O. Apinjoh & Lucas Amenga-Etego & Magnus Manske & John W. Barnwe, 2017. "Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution," Nature, Nature, vol. 542(7639), pages 101-104, February.
    4. Rachel Sendor & Kristin Banek & Melchior M. Kashamuka & Nono Mvuama & Joseph A. Bala & Marthe Nkalani & Georges Kihuma & Joseph Atibu & Kyaw L. Thwai & W. Matthew Svec & Varun Goel & Tommy Nseka & Jes, 2023. "Epidemiology of Plasmodium malariae and Plasmodium ovale spp. in Kinshasa Province, Democratic Republic of Congo," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
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