IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-54340-9.html
   My bibliography  Save this article

Ordered assemblies of peptide nanoparticles with only positive charge

Author

Listed:
  • Yi Shi

    (University of Delaware)

  • Tianren Zhang

    (University of Delaware
    University of Pennsylvania)

  • Rui Guo

    (University of Pennsylvania)

  • Zihan Zhang

    (University of Delaware)

  • Amanda L. McCahill

    (University of Delaware)

  • Yao Tang

    (University of Delaware)

  • Sabrina E. Liskey

    (University of Delaware)

  • Dai-Bei Yang

    (University of Pennsylvania)

  • Christopher J. Kloxin

    (University of Delaware
    University of Delaware)

  • Jeffery G. Saven

    (University of Pennsylvania)

  • Darrin J. Pochan

    (University of Delaware)

Abstract

Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil ‘bundlemer’ nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution behaviours to mixed charge-type (MC) counterparts with both positively and negatively charged side chains. Nematic and columnar liquid crystal phases are discovered in low concentrations of SC particles, indicative of particle end-to-end stacking into columns combined with lateral electrostatic repulsion between columns, while MC particles with the same net charge and particle shape produced only amorphous, soluble aggregates. Similarly, porous lattices are formed in mixtures of SC/MC particles of opposite charges while MC/MC mixtures of opposite charges produce only amorphous aggregates. The lattice structure is inferred with a machine learning optimization approach. The differences between SC and MC particle behaviours directly show the importance of surface electrostatic patchiness.

Suggested Citation

  • Yi Shi & Tianren Zhang & Rui Guo & Zihan Zhang & Amanda L. McCahill & Yao Tang & Sabrina E. Liskey & Dai-Bei Yang & Christopher J. Kloxin & Jeffery G. Saven & Darrin J. Pochan, 2024. "Ordered assemblies of peptide nanoparticles with only positive charge," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54340-9
    DOI: 10.1038/s41467-024-54340-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-54340-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-54340-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Dongdong Wu & Nairiti Sinha & Jeeyoung Lee & Bryan P. Sutherland & Nicole I. Halaszynski & Yu Tian & Jeffrey Caplan & Huixi Violet Zhang & Jeffery G. Saven & Christopher J. Kloxin & Darrin J. Pochan, 2019. "Polymers with controlled assembly and rigidity made with click-functional peptide bundles," Nature, Nature, vol. 574(7780), pages 658-662, October.
    2. Andreas Leitherer & Angelo Ziletti & Luca M. Ghiringhelli, 2021. "Robust recognition and exploratory analysis of crystal structures via Bayesian deep learning," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Rui Tian & Shuo Gao & Kaitao Li & Chao Lu, 2023. "Design of mechanical-robust phosphorescence materials through covalent click reaction," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Daniel Mark Shapiro & Gunasheil Mandava & Sibel Ebru Yalcin & Pol Arranz-Gibert & Peter J. Dahl & Catharine Shipps & Yangqi Gu & Vishok Srikanth & Aldo I. Salazar-Morales & J. Patrick O’Brien & Koen V, 2022. "Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54340-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.