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Next-generation rapid phenotypic antimicrobial susceptibility testing

Author

Listed:
  • Grace Reszetnik

    (McGill University
    University of Toronto)

  • Keely Hammond

    (McGill University Health Centre)

  • Sara Mahshid

    (McGill University)

  • Tamer AbdElFatah

    (McGill University)

  • Dao Nguyen

    (McGill University
    McGill University Health Centre
    Institute of the McGill University Health Centre)

  • Rachel Corsini

    (Institute of the McGill University Health Centre)

  • Chelsea Caya

    (Institute of the McGill University Health Centre)

  • Jesse Papenburg

    (Institute of the McGill University Health Centre
    McGill University Health Centre)

  • Matthew P. Cheng

    (McGill University Health Centre
    Institute of the McGill University Health Centre)

  • Cedric P. Yansouni

    (McGill University Health Centre
    Institute of the McGill University Health Centre
    McGill University)

Abstract

Slow progress towards implementation of conventional clinical bacteriology in low resource settings and strong interest in greater speed for antimicrobial susceptibility testing (AST) more generally has focused attention on next-generation rapid AST technologies. In this Review, we systematically synthesize publications and submissions to regulatory agencies describing technologies that provide phenotypic AST faster than conventional methods. We characterize over ninety technologies in terms of underlying technical innovations, technology readiness level, extent of clinical validation, and time-to-results. This work provides a guide for technology developers and clinical microbiologists to understand the rapid phenotypic AST technology landscape, current development pipeline, and AST-specific validation milestones.

Suggested Citation

  • Grace Reszetnik & Keely Hammond & Sara Mahshid & Tamer AbdElFatah & Dao Nguyen & Rachel Corsini & Chelsea Caya & Jesse Papenburg & Matthew P. Cheng & Cedric P. Yansouni, 2024. "Next-generation rapid phenotypic antimicrobial susceptibility testing," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53930-x
    DOI: 10.1038/s41467-024-53930-x
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    References listed on IDEAS

    as
    1. Vinodh Kandavalli & Praneeth Karempudi & Jimmy Larsson & Johan Elf, 2022. "Rapid antibiotic susceptibility testing and species identification for mixed samples," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Tae Hyun Kim & Junwon Kang & Haewook Jang & Hyelyn Joo & Gi Yoon Lee & Hamin Kim & Untack Cho & Hyeeun Bang & Jisung Jang & Sangkwon Han & Dong Young Kim & Chan Mi Lee & Chang Kyung Kang & Pyoeng Gyun, 2024. "Blood culture-free ultra-rapid antimicrobial susceptibility testing," Nature, Nature, vol. 632(8026), pages 893-902, August.
    Full references (including those not matched with items on IDEAS)

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