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The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly

Author

Listed:
  • Jianyong Chen

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

  • Jan Bartoš

    (Centre of Plant Structural and Functional Genomics)

  • Anastassia Boudichevskaia

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben
    KWS SAAT SE & Co. KGaA)

  • Anna Voigt

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

  • Mark Timothy Rabanus-Wallace

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben
    The University of Melbourne)

  • Steven Dreissig

    (Martin Luther University Halle-Wittenberg)

  • Zuzana Tulpová

    (Centre of Plant Structural and Functional Genomics)

  • Hana Šimková

    (Centre of Plant Structural and Functional Genomics)

  • Jiří Macas

    (Czech Academy of Sciences)

  • Gihwan Kim

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

  • Jonas Buhl

    (Leibniz Institute of Plant Biochemistry
    Philipps University Marburg)

  • Katharina Bürstenbinder

    (Leibniz Institute of Plant Biochemistry
    Philipps University Marburg)

  • Frank R. Blattner

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

  • Jörg Fuchs

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

  • Thomas Schmutzer

    (Martin Luther University Halle-Wittenberg)

  • Axel Himmelbach

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

  • Veit Schubert

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

  • Andreas Houben

    (Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben)

Abstract

The genomes of many plants, animals, and fungi frequently comprise dispensable B chromosomes that rely upon various chromosomal drive mechanisms to counteract the tendency of non-essential genetic elements to be purged over time. The B chromosome of rye – a model system for nearly a century – undergoes targeted nondisjunction during first pollen mitosis, favouring segregation into the generative nucleus, thus increasing their numbers over generations. However, the genetic mechanisms underlying this process are poorly understood. Here, using a newly-assembled, ~430 Mb-long rye B chromosome pseudomolecule, we identify five candidate genes whose role as trans-acting moderators of the chromosomal drive is supported by karyotyping, chromosome drive analysis and comparative RNA-seq. Among them, we identify DCR28, coding a microtubule-associated protein related to cell division, and detect this gene also in the B chromosome of Aegilops speltoides. The DCR28 gene family is neo-functionalised and serially-duplicated with 15 B chromosome-located copies that are uniquely highly expressed in the first pollen mitosis of rye.

Suggested Citation

  • Jianyong Chen & Jan Bartoš & Anastassia Boudichevskaia & Anna Voigt & Mark Timothy Rabanus-Wallace & Steven Dreissig & Zuzana Tulpová & Hana Šimková & Jiří Macas & Gihwan Kim & Jonas Buhl & Katharina , 2024. "The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53799-w
    DOI: 10.1038/s41467-024-53799-w
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    1. Stephen A. Schlebusch & Jakub Rídl & Manon Poignet & Francisco J. Ruiz-Ruano & Jiří Reif & Petr Pajer & Jan Pačes & Tomáš Albrecht & Alexander Suh & Radka Reifová, 2023. "Rapid gene content turnover on the germline-restricted chromosome in songbirds," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Cormac M. Kinsella & Francisco J. Ruiz-Ruano & Anne-Marie Dion-Côté & Alexander J. Charles & Toni I. Gossmann & Josefa Cabrero & Dennis Kappei & Nicola Hemmings & Mirre J. P. Simons & Juan Pedro M. Ca, 2019. "Programmed DNA elimination of germline development genes in songbirds," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
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    1. Stephen A. Schlebusch & Jakub Rídl & Manon Poignet & Francisco J. Ruiz-Ruano & Jiří Reif & Petr Pajer & Jan Pačes & Tomáš Albrecht & Alexander Suh & Radka Reifová, 2023. "Rapid gene content turnover on the germline-restricted chromosome in songbirds," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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