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Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers

Author

Listed:
  • Fang Liu

    (Zhejiang University
    Zhejiang University)

  • Yongcheng Chen

    (Zhejiang University)

  • Yue Huang

    (Zhejiang University)

  • Yutong Li

    (Zhejiang University)

  • Zhouyu Lu

    (Zhejiang University)

  • Haijie Han

    (Zhejiang University)

  • Xiaohui Song

    (Zhejiang University)

  • Qiao Jin

    (Zhejiang University
    Zhejiang University
    Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering)

  • Jian Ji

    (Zhejiang University
    Zhejiang University School of Medicine)

Abstract

Fungi are very common infectious pathogens, which may cause invasive and potentially life-threatening infections. However, the efficacy of antifungal medications remains limited. Herein, a Cu2+-phenolic nanoflower is designed to combat fungal infections by combining cuproptosis and cell wall digestion. Firstly, protocatechuic acid (PA)-Cu2+ (PC) nanopetals are prepared by coordination interaction. Lywallzyme (Lyw) is then added to induce the self-assembly of PC to form Lyw loaded PC (PCW) nanoflowers. PCW nanoflowers can effectively adhere to fungal surface and Lyw can digest fungal cell walls to facilitate Cu2+ to penetrate into fungal interior, thereby exerting a synergistic fungicidal effect. PCW nanoflowers exhibit excellent fungicidal activity even in protein-rich and high-salt conditions, where dissociative Cu2+ completely loses fungicidal activity. Transcriptome sequencing analysis reveals that PCW can lead to fungal cuproptosis. The in vivo fungicidal effect of PCW nanoflowers is confirmed on a murine skin fungal infection model and a murine fungal keratitis model.

Suggested Citation

  • Fang Liu & Yongcheng Chen & Yue Huang & Yutong Li & Zhouyu Lu & Haijie Han & Xiaohui Song & Qiao Jin & Jian Ji, 2024. "Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53410-2
    DOI: 10.1038/s41467-024-53410-2
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    References listed on IDEAS

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    1. Jiajing Zhou & Zhixing Lin & Matthew Penna & Shuaijun Pan & Yi Ju & Shiyao Li & Yiyuan Han & Jingqu Chen & Gan Lin & Joseph J. Richardson & Irene Yarovsky & Frank Caruso, 2020. "Particle engineering enabled by polyphenol-mediated supramolecular networks," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    2. Yanli Huang & Xufeng Wan & Qiang Su & Chunlin Zhao & Jian Cao & Yan Yue & Shuoyuan Li & Xiaoting Chen & Jie Yin & Yi Deng & Xianzeng Zhang & Tianmin Wu & Zongke Zhou & Duan Wang, 2024. "Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
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