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AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off

Author

Listed:
  • Zhen Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Norwich Research Park)

  • Xiaofan Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Chunyan Liu

    (Chinese Academy of Sciences)

  • Susan Duncan

    (Norwich Research Park)

  • Runlai Hang

    (Chinese Academy of Sciences)

  • Jing Sun

    (Chinese Academy of Sciences)

  • Lilan Luo

    (Chinese Academy of Sciences)

  • Yiliang Ding

    (Norwich Research Park)

  • Xiaofeng Cao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Translation, a fundamental process regulating cellular growth and proliferation, relies on functional ribosomes. As sessile organisms, plants have evolved adaptive strategies to maintain a delicate balance between growth and stress response. But the underlying mechanisms, particularly on the translational level, remain less understood. In this study, we revealed the mechanisms of AtPRMT3-RPS2B in orchestrating ribosome assembly and managing translational regulation. Through a forward genetic screen, we identified PDCD2-D1 as a suppressor gene restoring abnormal development and ribosome biogenesis in atprmt3-2 mutants. Our findings confirmed that PDCD2 interacts with AtPRMT3-RPS2B, and facilitates pre-ribosome transport through nuclear pore complex, finally ensuring normal ribosome translation in the cytoplasm. Additionally, the dysfunction of AtPRMT3-RPS2B was found to enhance freezing tolerance. Moreover, we revealed that AtPRMT3-RPS2B promotes the translation of housekeeping mRNAs while concurrently repressing stress-related mRNAs. In summary, our study sheds light on the regulatory roles of AtPRMT3-RPS2B in ribosome assembly and translational balance, enabling the trade-off between growth and stress.

Suggested Citation

  • Zhen Wang & Xiaofan Zhang & Chunyan Liu & Susan Duncan & Runlai Hang & Jing Sun & Lilan Luo & Yiliang Ding & Xiaofeng Cao, 2024. "AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52945-8
    DOI: 10.1038/s41467-024-52945-8
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    References listed on IDEAS

    as
    1. Guoyong Xu & George H. Greene & Heejin Yoo & Lijing Liu & Jorge Marqués & Jonathan Motley & Xinnian Dong, 2017. "Global translational reprogramming is a fundamental layer of immune regulation in plants," Nature, Nature, vol. 545(7655), pages 487-490, May.
    2. Xiaofeng Zu & Lilan Luo & Zhen Wang & Jie Gong & Chao Yang & Yong Wang & Chunhui Xu & Xinhua Qiao & Xian Deng & Xianwei Song & Chang Chen & Bao-Cai Tan & Xiaofeng Cao, 2023. "A mitochondrial pentatricopeptide repeat protein enhances cold tolerance by modulating mitochondrial superoxide in rice," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
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