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A selective frequency damping and Janus adhesive hydrogel as bioelectronic interfaces for clinical trials

Author

Listed:
  • Jiabei Luo

    (Donghua University)

  • Yuefan Jin

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Linpeng Li

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Boya Chang

    (Donghua University)

  • Bin Zhang

    (Donghua University)

  • Kerui Li

    (Donghua University)

  • Yaogang Li

    (Donghua University)

  • Qinghong Zhang

    (Donghua University)

  • Hongzhi Wang

    (Donghua University)

  • Jing Wang

    (ETH Zürich
    Empa – Swiss Federal Laboratories for Materials Science and Technology)

  • Shankai Yin

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Hui Wang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Chengyi Hou

    (Donghua University)

Abstract

Maintaining stillness is essential for accurate bioelectrical signal acquisition, but dynamic noise from breathing remains unavoidable. Isotropic adhesives are often used as bioelectronic interfaces to ensure signal fidelity, but they can leave irreversible residues, compromising device accuracy. We propose a hydrogel with selective frequency damping and asymmetric adhesion as a bioelectronic interface. This hydrogel mitigates dynamic noise from breathing, with a damping effect in the breathing frequency range 60 times greater than at other frequencies. It also exhibits an asymmetric adhesion difference of up to 537 times, preventing residues. By homogenizing ion distribution, extending Debye length, and densifying the electric field, the hydrogel ensures stable signal transmission over 10,000 cycles. Additionally, it can non-invasively diagnose otitis media with higher sensitivity than invasive probes and has been effective in clinical polysomnography monitoring, aiding in the diagnosis of obstructive sleep apnea.

Suggested Citation

  • Jiabei Luo & Yuefan Jin & Linpeng Li & Boya Chang & Bin Zhang & Kerui Li & Yaogang Li & Qinghong Zhang & Hongzhi Wang & Jing Wang & Shankai Yin & Hui Wang & Chengyi Hou, 2024. "A selective frequency damping and Janus adhesive hydrogel as bioelectronic interfaces for clinical trials," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52833-1
    DOI: 10.1038/s41467-024-52833-1
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    References listed on IDEAS

    as
    1. Binbin Zhang & Jiyu Li & Jingkun Zhou & Lung Chow & Guangyao Zhao & Ya Huang & Zhiqiang Ma & Qiang Zhang & Yawen Yang & Chun Ki Yiu & Jian Li & Fengjun Chun & Xingcan Huang & Yuyu Gao & Pengcheng Wu &, 2024. "A three-dimensional liquid diode for soft, integrated permeable electronics," Nature, Nature, vol. 628(8006), pages 84-92, April.
    2. Yutong He & Qian Li & Pinger Chen & Qixiang Duan & Jiamian Zhan & Xiaohui Cai & Leyu Wang & Honghao Hou & Xiaozhong Qiu, 2022. "A smart adhesive Janus hydrogel for non-invasive cardiac repair and tissue adhesion prevention," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
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