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Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications

Author

Listed:
  • Wonmoon Song

    (Seoul National University)

  • Changyub Lee

    (Seoul National University)

  • Haein Jeong

    (Seoul National University)

  • Seoyeon Kim

    (Seoul National University)

  • Nathaniel S. Hwang

    (Seoul National University
    Seoul National University)

Abstract

Post-surgical adhesions frequently occur after intra-abdominal surgery, leading to severe complications. Despite the development of various types of adhesion barriers to address post-surgical adhesions, several limitations persist, including off-target localization, handling difficulties, and potential immunogenicity. Here, we report a spray-type adhesion barrier for broad, fast application, forming two sequential networks. The first network is formed by a polyelectrolyte complex of sulfated hyaluronic acid and chitosan, while the second network is established through pluronic® F127 thermogelation. This sprayable barrier served as both a physical protector for the damaged peritoneum and an immunomodulator for peritoneal macrophages, as evidenced its effectiveness in a rat ischemic button model. Taken together, this efficient adhesion barrier presents a promising solution for post-surgical adhesions.

Suggested Citation

  • Wonmoon Song & Changyub Lee & Haein Jeong & Seoyeon Kim & Nathaniel S. Hwang, 2024. "Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52753-0
    DOI: 10.1038/s41467-024-52753-0
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    References listed on IDEAS

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    1. Masaki Fujita & Gina M. Policastro & Austin Burdick & Hillary T. Lam & Jessica L. Ungerleider & Rebecca L. Braden & Diane Huang & Kent G. Osborn & Jeffrey H. Omens & Michael M. Madani & Karen L. Chris, 2021. "Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
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