IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-24104-w.html
   My bibliography  Save this article

Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel

Author

Listed:
  • Masaki Fujita

    (University of California, San Diego
    University of California, San Diego)

  • Gina M. Policastro

    (University of California, San Diego
    University of California, San Diego)

  • Austin Burdick

    (University of California, San Diego
    University of California, San Diego)

  • Hillary T. Lam

    (University of California, San Diego
    University of California, San Diego)

  • Jessica L. Ungerleider

    (University of California, San Diego
    University of California, San Diego)

  • Rebecca L. Braden

    (University of California, San Diego
    University of California, San Diego)

  • Diane Huang

    (University of California, San Diego)

  • Kent G. Osborn

    (University of California, San Diego)

  • Jeffrey H. Omens

    (University of California, San Diego
    University of California, San Diego)

  • Michael M. Madani

    (University of California, San Diego)

  • Karen L. Christman

    (University of California, San Diego
    University of California, San Diego)

Abstract

Post-surgical cardiac adhesions represent a significant problem during routine cardiothoracic procedures. This fibrous tissue can impair heart function and inhibit surgical access in reoperation procedures. Here, we propose a hydrogel barrier composed of oxime crosslinked poly(ethylene glycol) (PEG) with the inclusion of a catechol (Cat) group to improve retention on the heart for pericardial adhesion prevention. This three component system is comprised of aldehyde (Ald), aminooxy (AO), and Cat functionalized PEG mixed to form the final gel (Ald-AO-Cat). Ald-AO-Cat has favorable mechanical properties, degradation kinetics, and minimal swelling, as well as superior tissue retention compared to an initial Ald-AO gel formulation. We show that the material is cytocompatible, resists cell adhesion, and led to a reduction in the severity of adhesions in an in vivo rat model. We further show feasibility in a pilot porcine study. The Ald-AO-Cat hydrogel barrier may therefore serve as a promising solution for preventing post-surgical cardiac adhesions.

Suggested Citation

  • Masaki Fujita & Gina M. Policastro & Austin Burdick & Hillary T. Lam & Jessica L. Ungerleider & Rebecca L. Braden & Diane Huang & Kent G. Osborn & Jeffrey H. Omens & Michael M. Madani & Karen L. Chris, 2021. "Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24104-w
    DOI: 10.1038/s41467-021-24104-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-24104-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-24104-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chaojie Yu & Mingyue Shi & Shaoshuai He & Mengmeng Yao & Hong Sun & Zhiwei Yue & Yuwei Qiu & Baijun Liu & Lei Liang & Zhongming Zhao & Fanglian Yao & Hong Zhang & Junjie Li, 2023. "Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Wonmoon Song & Changyub Lee & Haein Jeong & Seoyeon Kim & Nathaniel S. Hwang, 2024. "Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24104-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.