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Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel

Author

Listed:
  • Masaki Fujita

    (University of California, San Diego
    University of California, San Diego)

  • Gina M. Policastro

    (University of California, San Diego
    University of California, San Diego)

  • Austin Burdick

    (University of California, San Diego
    University of California, San Diego)

  • Hillary T. Lam

    (University of California, San Diego
    University of California, San Diego)

  • Jessica L. Ungerleider

    (University of California, San Diego
    University of California, San Diego)

  • Rebecca L. Braden

    (University of California, San Diego
    University of California, San Diego)

  • Diane Huang

    (University of California, San Diego)

  • Kent G. Osborn

    (University of California, San Diego)

  • Jeffrey H. Omens

    (University of California, San Diego
    University of California, San Diego)

  • Michael M. Madani

    (University of California, San Diego)

  • Karen L. Christman

    (University of California, San Diego
    University of California, San Diego)

Abstract

Post-surgical cardiac adhesions represent a significant problem during routine cardiothoracic procedures. This fibrous tissue can impair heart function and inhibit surgical access in reoperation procedures. Here, we propose a hydrogel barrier composed of oxime crosslinked poly(ethylene glycol) (PEG) with the inclusion of a catechol (Cat) group to improve retention on the heart for pericardial adhesion prevention. This three component system is comprised of aldehyde (Ald), aminooxy (AO), and Cat functionalized PEG mixed to form the final gel (Ald-AO-Cat). Ald-AO-Cat has favorable mechanical properties, degradation kinetics, and minimal swelling, as well as superior tissue retention compared to an initial Ald-AO gel formulation. We show that the material is cytocompatible, resists cell adhesion, and led to a reduction in the severity of adhesions in an in vivo rat model. We further show feasibility in a pilot porcine study. The Ald-AO-Cat hydrogel barrier may therefore serve as a promising solution for preventing post-surgical cardiac adhesions.

Suggested Citation

  • Masaki Fujita & Gina M. Policastro & Austin Burdick & Hillary T. Lam & Jessica L. Ungerleider & Rebecca L. Braden & Diane Huang & Kent G. Osborn & Jeffrey H. Omens & Michael M. Madani & Karen L. Chris, 2021. "Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24104-w
    DOI: 10.1038/s41467-021-24104-w
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    Cited by:

    1. Chaojie Yu & Mingyue Shi & Shaoshuai He & Mengmeng Yao & Hong Sun & Zhiwei Yue & Yuwei Qiu & Baijun Liu & Lei Liang & Zhongming Zhao & Fanglian Yao & Hong Zhang & Junjie Li, 2023. "Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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