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Engineering tunable catch bonds with DNA

Author

Listed:
  • Micah Yang

    (The University of British Columbia)

  • David t. R. Bakker

    (The University of British Columbia)

  • Isaac T. S. Li

    (The University of British Columbia)

Abstract

Unlike most adhesive bonds, biological catch bonds strengthen with increased tension. This characteristic is essential to specific receptor-ligand interactions, underpinning biological adhesion dynamics, cell communication, and mechanosensing. While artificial catch bonds have been conceived, the tunability of their catch behaviour is limited. Here, we present the fish-hook, a rationally designed DNA catch bond that can be finely adjusted to a wide range of catch behaviours. We develop models to design these DNA structures and experimentally validate different catch behaviours by single-molecule force spectroscopy. The fish-hook architecture supports a vast sequence-dependent behaviour space, making it a valuable tool for reprogramming biological interactions and engineering force-strengthening materials.

Suggested Citation

  • Micah Yang & David t. R. Bakker & Isaac T. S. Li, 2024. "Engineering tunable catch bonds with DNA," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52749-w
    DOI: 10.1038/s41467-024-52749-w
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    References listed on IDEAS

    as
    1. Ion Andreu & Bryan Falcones & Sebastian Hurst & Nimesh Chahare & Xarxa Quiroga & Anabel-Lise Roux & Zanetta Kechagia & Amy E. M. Beedle & Alberto Elosegui-Artola & Xavier Trepat & Ramon Farré & Timo B, 2021. "The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Kerim C. Dansuk & Sinan Keten, 2021. "Self-strengthening biphasic nanoparticle assemblies with intrinsic catch bonds," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
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