IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-52668-w.html
   My bibliography  Save this article

Immune escape and attenuated severity associated with the SARS-CoV-2 BA.2.86/JN.1 lineage

Author

Listed:
  • Joseph A. Lewnard

    (University of California, Berkeley)

  • Parag Mahale

    (Kaiser Permanente Southern California)

  • Debbie Malden

    (Kaiser Permanente Southern California)

  • Vennis Hong

    (Kaiser Permanente Southern California)

  • Bradley K. Ackerson

    (Kaiser Permanente Southern California)

  • Bruno J. Lewin

    (Kaiser Permanente Southern California)

  • Ruth Link-Gelles

    (US Centers for Disease Control & Prevention)

  • Leora R. Feldstein

    (Centers for Disease Control and Prevention)

  • Marc Lipsitch

    (Centers for Disease Control and Prevention)

  • Sara Y. Tartof

    (Kaiser Permanente Southern California
    Kaiser Permanente Bernard J. Tyson School of Medicine)

Abstract

The SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1 emergence, we compared characteristics and clinical outcomes of time-matched cases infected with BA.2.86 lineages (predominantly representing JN.1) versus co-circulating XBB-derived lineages in December, 2023 and January, 2024. Cases infected with BA.2.86 lineages received greater numbers of COVID-19 vaccine doses, including XBB.1.5-targeted boosters, in comparison to cases infected with XBB-derived lineages. Additionally, cases infected with BA.2.86 lineages experienced greater numbers of documented prior SARS-CoV-2 infections. Cases infected with BA.2.86 lineages also experienced lower risk of progression to severe clinical outcomes requiring emergency department consultations or hospital admission. Sensitivity analyses suggested under-ascertainment of prior infections could not explain this apparent attenuation of severity. Our findings implicate escape from immunity acquired from prior vaccination or infection in the emergence of the JN.1 lineage and suggest infections with this lineage are less likely to experience clinically-severe disease. Monitoring of immune escape and clinical severity in emerging SARS-CoV-2 variants remains a priority to inform responses.

Suggested Citation

  • Joseph A. Lewnard & Parag Mahale & Debbie Malden & Vennis Hong & Bradley K. Ackerson & Bruno J. Lewin & Ruth Link-Gelles & Leora R. Feldstein & Marc Lipsitch & Sara Y. Tartof, 2024. "Immune escape and attenuated severity associated with the SARS-CoV-2 BA.2.86/JN.1 lineage," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52668-w
    DOI: 10.1038/s41467-024-52668-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-52668-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-52668-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Joseph A. Lewnard & Vennis Hong & Jeniffer S. Kim & Sally F. Shaw & Bruno Lewin & Harpreet Takhar & Sara Y. Tartof, 2023. "Association of SARS-CoV-2 BA.4/BA.5 Omicron lineages with immune escape and clinical outcome," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Honaker, James & King, Gary & Blackwell, Matthew, 2011. "Amelia II: A Program for Missing Data," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 45(i07).
    3. Joseph A. Lewnard & Vennis Hong & Jeniffer S. Kim & Sally F. Shaw & Bruno Lewin & Harpreet Takhar & Marc Lipsitch & Sara Y. Tartof, 2023. "Increased vaccine sensitivity of an emerging SARS-CoV-2 variant," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Joseph A. Lewnard & Vennis Hong & Jeniffer S. Kim & Sally F. Shaw & Bruno Lewin & Harpreet Takhar & Marc Lipsitch & Sara Y. Tartof, 2023. "Increased vaccine sensitivity of an emerging SARS-CoV-2 variant," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Robert A. Jackson & Matthew Pietryka, 2022. "The influence of becoming a parent on political participation in the United States," Social Science Quarterly, Southwestern Social Science Association, vol. 103(3), pages 565-580, May.
    3. Cohen, Joseph N, 2010. "Neoliberalism’s relationship with economic growth in the developing world: Was it the power of the market or the resolution of financial crisis?," MPRA Paper 24527, University Library of Munich, Germany.
    4. Matei Demetrescu & Christoph Hanck & Robinson Kruse‐Becher, 2022. "Robust inference under time‐varying volatility: A real‐time evaluation of professional forecasters," Journal of Applied Econometrics, John Wiley & Sons, Ltd., vol. 37(5), pages 1010-1030, August.
    5. Hassan, Mahmoud & Oueslati, Walid & Rousselière, Damien, 2020. "Environmental taxes, reforms and economic growth: an empirical analysis of panel data," Economic Systems, Elsevier, vol. 44(3).
    6. Segaro, Ethiopia L. & Larimo, Jorma & Jones, Marian V., 2014. "Internationalisation of family small and medium sized enterprises: The role of stewardship orientation, family commitment culture and top management team," International Business Review, Elsevier, vol. 23(2), pages 381-395.
    7. Shige Song, 2013. "Prenatal malnutrition and subsequent foetal loss risk: Evidence from the 1959-1961 Chinese famine," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 29(26), pages 707-728.
    8. Phillipp Schwarzfischer & Dariusz Gruszfeld & Piotr Socha & Veronica Luque & Ricardo Closa-Monasterolo & Déborah Rousseaux & Melissa Moretti & Alice ReDionigi & Elvira Verduci & Berthold Koletzko & Ve, 2020. "Effects of screen time and playing outside on anthropometric measures in preschool aged children," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-15, March.
    9. Joseph A. Lewnard & Vennis Hong & Jeniffer S. Kim & Sally F. Shaw & Bruno Lewin & Harpreet Takhar & Sara Y. Tartof, 2023. "Association of SARS-CoV-2 BA.4/BA.5 Omicron lineages with immune escape and clinical outcome," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    10. Abdulelah Alkesaiberi & Fouzi Harrou & Ying Sun, 2022. "Efficient Wind Power Prediction Using Machine Learning Methods: A Comparative Study," Energies, MDPI, vol. 15(7), pages 1-24, March.
    11. Lara Lopez & Fernando L. Vázquez & Ángela J. Torres & Patricia Otero & Vanessa Blanco & Olga Díaz & Mario Páramo, 2020. "Long-Term Effects of a Cognitive Behavioral Conference Call Intervention on Depression in Non-Professional Caregivers," IJERPH, MDPI, vol. 17(22), pages 1-24, November.
    12. Jessica L. Schleider & Michael C. Mullarkey & Kathryn R. Fox & Mallory L. Dobias & Akash Shroff & Erica A. Hart & Chantelle A. Roulston, 2022. "A randomized trial of online single-session interventions for adolescent depression during COVID-19," Nature Human Behaviour, Nature, vol. 6(2), pages 258-268, February.
    13. Baltagi, Badi H. & Bresson, Georges & Chaturvedi, Anoop & Lacroix, Guy, 2022. "Robust Dynamic Space-Time Panel Data Models Using ?-Contamination: An Application to Crop Yields and Climate Change," IZA Discussion Papers 15815, Institute of Labor Economics (IZA).
    14. Dujardin, Jérôme & Kahl, Annelen & Kruyt, Bert & Bartlett, Stuart & Lehning, Michael, 2017. "Interplay between photovoltaic, wind energy and storage hydropower in a fully renewable Switzerland," Energy, Elsevier, vol. 135(C), pages 513-525.
    15. Andrasfay, Theresa & Goldman, Noreen, 2020. "Physical functioning and survival: Is the link weaker among Latino and black older adults?," Social Science & Medicine, Elsevier, vol. 255(C).
    16. Nam Kyu Kim, 2018. "Revolutionary Leaders and Mass Killing," Journal of Conflict Resolution, Peace Science Society (International), vol. 62(2), pages 289-317, February.
    17. Jonathan B Slapin, 2014. "Measurement, model testing, and legislative influence in the European Union," European Union Politics, , vol. 15(1), pages 24-42, March.
    18. Matei Demetrescu & Christoph Hanck & Robinson Kruse, 2016. "Fixed-b Inference in the Presence of Time-Varying Volatility," CREATES Research Papers 2016-01, Department of Economics and Business Economics, Aarhus University.
    19. Seiler, Christian & Heumann, Christian, 2013. "Microdata imputations and macrodata implications: Evidence from the Ifo Business Survey," Economic Modelling, Elsevier, vol. 35(C), pages 722-733.
    20. Mattia Guidi, 2015. "The Impact of Independence on Regulatory Outcomes: the Case of EU Competition Policy," Journal of Common Market Studies, Wiley Blackwell, vol. 53(6), pages 1195-1213, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52668-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.