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SURF2 is a MDM2 antagonist in triggering the nucleolar stress response

Author

Listed:
  • Sophie Tagnères

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Paulo Espirito Santo

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Julie Radermecker

    (CEDEX 08)

  • Dana Rinaldi

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Carine Froment

    (Université Toulouse III-Paul Sabatier (UPS)
    ProFI)

  • Quentin Provost

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Manon Bongers

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Solemne Capeille

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Nick Watkins

    (Newcastle University)

  • Julien Marcoux

    (Université Toulouse III-Paul Sabatier (UPS)
    ProFI)

  • Pierre-Emmanuel Gleizes

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Virginie Marcel

    (CEDEX 08)

  • Célia Plisson-Chastang

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne)

  • Simon Lebaron

    (University of Toulouse, CNRS, UPS, 118 route de Narbonne
    Institut national de la santé et de la recherche médicale (INSERM))

Abstract

Cancer cells rely on high ribosome production to sustain their proliferation rate. Many chemotherapies impede ribosome production which is perceived by cells as “nucleolar stress” (NS), triggering p53-dependent and independent pathways leading to cell cycle arrest and/or apoptosis. The 5S ribonucleoprotein (RNP) particle, a sub-ribosomal particle, is instrumental to NS response. Upon ribosome assembly defects, the 5S RNP accumulates as free form. This free form is able to sequester and inhibit MDM2, thus promoting p53 stabilization. To investigate how cancer cells can resist to NS, here we purify free 5S RNP and uncover an interaction partner, SURF2. Functional characterization of SURF2 shows that its depletion increases cellular sensitivity to NS, while its overexpression promotes their resistance to it. Consistently, SURF2 is overexpressed in many cancers and its expression level is an independent marker of prognosis for adrenocortical cancer. Our data demonstrate that SURF2 buffers free 5S RNP particles, and can modulate their activity, paving the way for the research of new molecules that can finely tune the response to nucleolar stress in the framework of cancer therapies.

Suggested Citation

  • Sophie Tagnères & Paulo Espirito Santo & Julie Radermecker & Dana Rinaldi & Carine Froment & Quentin Provost & Manon Bongers & Solemne Capeille & Nick Watkins & Julien Marcoux & Pierre-Emmanuel Gleize, 2024. "SURF2 is a MDM2 antagonist in triggering the nucleolar stress response," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52659-x
    DOI: 10.1038/s41467-024-52659-x
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    References listed on IDEAS

    as
    1. Emilien Nicolas & Pascaline Parisot & Celina Pinto-Monteiro & Roxane de Walque & Christophe De Vleeschouwer & Denis L. J. Lafontaine, 2016. "Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    2. Shengjiang Tan & Laëtitia Kermasson & Christine Hilcenko & Vasileios Kargas & David Traynor & Ahmed Z. Boukerrou & Norberto Escudero-Urquijo & Alexandre Faille & Alexis Bertrand & Maxim Rossmann & Bea, 2021. "Somatic genetic rescue of a germline ribosome assembly defect," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
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