IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-52396-1.html
   My bibliography  Save this article

Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression

Author

Listed:
  • Xin Huang

    (The University of Melbourne
    Level 11)

  • Chris Fowler

    (The University of Melbourne)

  • Yihan Li

    (The University of Melbourne)

  • Qiao-Xin Li

    (The University of Melbourne
    The University of Melbourne)

  • Jiaqi Sun

    (The University of Melbourne)

  • Yijun Pan

    (The University of Melbourne)

  • Liang Jin

    (The University of Melbourne)

  • Keyla A. Perez

    (The University of Melbourne)

  • Céline Dubois

    (The University of Melbourne)

  • Yen Y. Lim

    (Monash University)

  • Candace Drysdale

    (The University of Melbourne)

  • Rebecca L. Rumble

    (The University of Melbourne)

  • Holly R. Chinnery

    (The University of Melbourne
    Lions Eye Institute
    The University of Western Australia)

  • Christopher C. Rowe

    (Austin Health)

  • Ralph N. Martins

    (Edith Cowan University)

  • Paul Maruff

    (The University of Melbourne
    Cogstate Ltd.)

  • James D. Doecke

    (Australian E-Health Research Center, CSIRO)

  • Yong Lin

    (Fudan University)

  • Abdel A. Belaidi

    (The University of Melbourne)

  • Kevin J. Barnham

    (The University of Melbourne)

  • Colin L. Masters

    (The University of Melbourne)

  • Ben J. Gu

    (The University of Melbourne
    Level 11
    Fudan University)

Abstract

Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to identify Aβ-binding monocytes in blood, validated by confocal microscopy, Western blotting, and mass spectrometry. Flow cytometry immunophenotyping and correlation with AD biomarkers are studied in 150 participants from the AIBL study. We also examine monocytes in human cerebrospinal fluid (CSF) and their migration in an APP/PS1 mouse model. The assay reveals macrophage-like Aβ-binding monocytes with high phagocytic potential in both the periphery and CNS. We find lower surface Aβ levels in mild cognitive impairment (MCI) and AD-dementia patients compared to cognitively unimpaired individuals. Monocyte infiltration from blood to CSF and migration from CNS to peripheral lymph nodes and blood are observed. Here we show that Aβ-binding monocytes may play a role in CNS Aβ clearance, suggesting their potential as a biomarker for AD diagnosis and monitoring.

Suggested Citation

  • Xin Huang & Chris Fowler & Yihan Li & Qiao-Xin Li & Jiaqi Sun & Yijun Pan & Liang Jin & Keyla A. Perez & Céline Dubois & Yen Y. Lim & Candace Drysdale & Rebecca L. Rumble & Holly R. Chinnery & Christo, 2024. "Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52396-1
    DOI: 10.1038/s41467-024-52396-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-52396-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-52396-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Mitchell H. Murdock & Cheng-Yi Yang & Na Sun & Ping-Chieh Pao & Cristina Blanco-Duque & Martin C. Kahn & TaeHyun Kim & Nicolas S. Lavoie & Matheus B. Victor & Md Rezaul Islam & Fabiola Galiana & Noell, 2024. "Multisensory gamma stimulation promotes glymphatic clearance of amyloid," Nature, Nature, vol. 627(8002), pages 149-156, March.
    2. Akinori Nakamura & Naoki Kaneko & Victor L. Villemagne & Takashi Kato & James Doecke & Vincent Doré & Chris Fowler & Qiao-Xin Li & Ralph Martins & Christopher Rowe & Taisuke Tomita & Katsumi Matsuzaki, 2018. "High performance plasma amyloid-β biomarkers for Alzheimer’s disease," Nature, Nature, vol. 554(7691), pages 249-254, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Daniela Rodrigues-Amorim & P. Lorenzo Bozzelli & TaeHyun Kim & Liwang Liu & Oliver Gibson & Cheng-Yi Yang & Mitchell H. Murdock & Fabiola Galiana-Melendez & Brooke Schatz & Alexis Davison & Md Rezaul , 2024. "Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Kazumasa Yamada & Kenta Murotani & Makiko Mano & Youngmi Lim & Jun Yoshimatsu, 2023. "Age-Friendly Approach Is Necessary to Prevent Depopulation: Resident Architectural Designers and Constructors’ Evaluation of the Age-Friendliness of Japanese Municipalities," IJERPH, MDPI, vol. 20(17), pages 1-11, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52396-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.