IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-52290-w.html
   My bibliography  Save this article

Optimal level of human intracranial theta activity for behavioral switching in the subthalamo-medio-prefrontal circuit

Author

Listed:
  • Maëva Laquitaine

    (GIN)

  • Mircea Polosan

    (Grenoble Institut Neurosciences)

  • Philippe Kahane

    (Grenoble Institut Neurosciences)

  • Stephan Chabardes

    (Grenoble Institut Neurosciences)

  • Jérôme Yelnik

    (NeuroSpin center)

  • Sara Fernandez-Vidal

    (NeuroSpin center)

  • Philippe Domenech

    (NeuroSpin center
    Université Paris Cité)

  • Julien Bastin

    (GIN)

Abstract

The ability to switch between rules associating stimuli and responses depend on a circuit including the dorsomedial prefrontal cortex (dmPFC) and the subthalamic nucleus (STN). However, the precise neural implementations of switching remain unclear. To address this issue, we recorded local field potentials from the STN and from the dmPFC of neuropsychiatric patients during behavioral switching. Drift-diffusion modeling revealed that switching is associated with a shift in the starting point of evidence accumulation. Theta activity increases in dmPFC and STN during successful switch trials, while temporally delayed and excessive levels of theta lead to premature switch errors. This seemingly opposing impact of increased theta in successful and unsuccessful switching is explained by a negative correlation between theta activity and the starting point. Together, these results shed a new light on the neural mechanisms underlying the rapid reconfiguration of stimulus-response associations, revealing a Goldilocks’ effect of theta activity on switching behavior.

Suggested Citation

  • Maëva Laquitaine & Mircea Polosan & Philippe Kahane & Stephan Chabardes & Jérôme Yelnik & Sara Fernandez-Vidal & Philippe Domenech & Julien Bastin, 2024. "Optimal level of human intracranial theta activity for behavioral switching in the subthalamo-medio-prefrontal circuit," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52290-w
    DOI: 10.1038/s41467-024-52290-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-52290-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-52290-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Marije ter Wal & Artem Platonov & Pasquale Cardellicchio & Veronica Pelliccia & Giorgio LoRusso & Ivana Sartori & Pietro Avanzini & Guy A. Orban & Paul H. E. Tiesinga, 2020. "Human stereoEEG recordings reveal network dynamics of decision-making in a rule-switching task," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    2. Antoine Collomb-Clerc & Maëlle C. M. Gueguen & Lorella Minotti & Philippe Kahane & Vincent Navarro & Fabrice Bartolomei & Romain Carron & Jean Regis & Stephan Chabardès & Stefano Palminteri & Julien B, 2023. "Human thalamic low-frequency oscillations correlate with expected value and outcomes during reinforcement learning," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Sameer A. Sheth & Matthew K. Mian & Shaun R. Patel & Wael F. Asaad & Ziv M. Williams & Darin D. Dougherty & George Bush & Emad N. Eskandar, 2012. "Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation," Nature, Nature, vol. 488(7410), pages 218-221, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jan Weber & Anne-Kristin Solbakk & Alejandro O. Blenkmann & Anais Llorens & Ingrid Funderud & Sabine Leske & Pål Gunnar Larsson & Jugoslav Ivanovic & Robert T. Knight & Tor Endestad & Randolph F. Helf, 2024. "Ramping dynamics and theta oscillations reflect dissociable signatures during rule-guided human behavior," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Tao Yao & Wim Vanduffel, 2022. "Neuronal congruency effects in macaque prefrontal cortex," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Tao Xie & Markus Adamek & Hohyun Cho & Matthew A. Adamo & Anthony L. Ritaccio & Jon T. Willie & Peter Brunner & Jan Kubanek, 2024. "Graded decisions in the human brain," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Jiayang Xiao & Joshua A. Adkinson & John Myers & Anusha B. Allawala & Raissa K. Mathura & Victoria Pirtle & Ricardo Najera & Nicole R. Provenza & Eleonora Bartoli & Andrew J. Watrous & Denise Oswalt &, 2024. "Beta activity in human anterior cingulate cortex mediates reward biases," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Anne-Simone Armbrecht & Henning Gibbons & Jutta Stahl, 2013. "Effects of Response Force Parameters on Medial-Frontal Negativity," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-13, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52290-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.