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Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors

Author

Listed:
  • Paula A. Clark

    (MRC Laboratory of Molecular Biology)

  • Mayuri Gogoi

    (MRC Laboratory of Molecular Biology)

  • Noe Rodriguez-Rodriguez

    (MRC Laboratory of Molecular Biology)

  • Ana C. F. Ferreira

    (MRC Laboratory of Molecular Biology)

  • Jane E. Murphy

    (MRC Laboratory of Molecular Biology)

  • Jennifer A. Walker

    (MRC Laboratory of Molecular Biology)

  • Alastair Crisp

    (MRC Laboratory of Molecular Biology)

  • Helen E. Jolin

    (MRC Laboratory of Molecular Biology)

  • Jacqueline D. Shields

    (University of Nottingham Biodiscovery Institute)

  • Andrew N. J. McKenzie

    (MRC Laboratory of Molecular Biology)

Abstract

Innate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during infection and inflammation. Here we identify, by using combinatorial reporter mice, a rare ILC progenitor (ILCP) population, resident to the small intestinal lamina propria (siLP) in adult mice. Transfer of siLP-ILCP into recipients generates group 1 ILCs (including ILC1 and NK cells), ILC2s and ILC3s within the intestinal microenvironment, but almost exclusively group 1 ILCs in the liver, lung and spleen. Single cell gene expression analysis and high dimensional spectral cytometry analysis of the siLP-ILCPs and ILC progeny indicate that the phenotype of the group 1 ILC progeny is also influenced by the tissue microenvironment. Thus, a local pool of siLP-ILCP can contribute to pan-ILC generation in the intestinal microenvironment but has more restricted potential in other tissues, with a greater propensity than bone marrow-derived ILCPs to favour ILC1 and ILC3 production. Therefore, ILCP potential is influenced by both tissue of origin and the microenvironment during development. This may provide additional flexibility during the tuning of immune reactions.

Suggested Citation

  • Paula A. Clark & Mayuri Gogoi & Noe Rodriguez-Rodriguez & Ana C. F. Ferreira & Jane E. Murphy & Jennifer A. Walker & Alastair Crisp & Helen E. Jolin & Jacqueline D. Shields & Andrew N. J. McKenzie, 2024. "Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52155-2
    DOI: 10.1038/s41467-024-52155-2
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    References listed on IDEAS

    as
    1. Michael G. Constantinides & Benjamin D. McDonald & Philip A. Verhoef & Albert Bendelac, 2014. "A committed precursor to innate lymphoid cells," Nature, Nature, vol. 508(7496), pages 397-401, April.
    2. Isaac Dean & Colin Y. C. Lee & Zewen K. Tuong & Zhi Li & Christopher A. Tibbitt & Claire Willis & Fabrina Gaspal & Bethany C. Kennedy & Veronika Matei-Rascu & RĂ©mi Fiancette & Caroline Nordenvall & Ul, 2024. "Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
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