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An epigenetically mediated double negative cascade from EFD to HB21 regulates anther development

Author

Listed:
  • Cheng Zhang

    (Shanghai Normal University)

  • Ao-Tong Xiong

    (Shanghai Normal University)

  • Meng-Yi Ren

    (Shanghai Normal University)

  • Yan-Yun Zhao

    (Shanghai Normal University)

  • Min-Jia Huang

    (Shanghai Normal University)

  • Long-Cheng Huang

    (Shanghai Normal University)

  • Zheng Zhang

    (Shanghai Normal University)

  • Yun Wang

    (Shanghai Normal University)

  • Quan-Quan Zheng

    (Shanghai Normal University)

  • Jing Fan

    (Shanghai Normal University)

  • Jing-Jing Guan

    (Shanghai Normal University)

  • Zhong-Nan Yang

    (Shanghai Normal University)

Abstract

Epigenetic modifications are crucial for plant development. EFD (Exine Formation Defect) encodes a SAM-dependent methyltransferase that is essential for the pollen wall pattern formation and male fertility in Arabidopsis. In this study, we find that the expression of DRM2, a de novo DNA methyltransferase in plants, complements for the defects in efd, suggesting its potential de novo DNA methyltransferase activity. Genetic analysis indicates that EFD functions through HB21, as the knockout of HB21 fully restores fertility in efd mutants. DNA methylation and histone modification analyses reveal that EFD represses the transcription of HB21 through epigenetic mechanisms. Additionally, we demonstrate that HB21 directly represses the expression of genes crucial for pollen formation and anther dehiscence, including CalS5, RPG1/SWEET8, CYP703A2 and NST2. Collectively, our findings unveil a double negative regulatory cascade mediated by epigenetic modifications that coordinates anther development, offering insights into the epigenetic regulation of this process.

Suggested Citation

  • Cheng Zhang & Ao-Tong Xiong & Meng-Yi Ren & Yan-Yun Zhao & Min-Jia Huang & Long-Cheng Huang & Zheng Zhang & Yun Wang & Quan-Quan Zheng & Jing Fan & Jing-Jing Guan & Zhong-Nan Yang, 2024. "An epigenetically mediated double negative cascade from EFD to HB21 regulates anther development," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52114-x
    DOI: 10.1038/s41467-024-52114-x
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    References listed on IDEAS

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    1. Ruiqiang Ye & Meiyue Wang & Hao Du & Shweta Chhajed & Jin Koh & Kun-hsiang Liu & Jinwoo Shin & Yue Wu & Lin Shi & Lin Xu & Sixue Chen & Yijing Zhang & Jen Sheen, 2022. "Glucose-driven TOR–FIE–PRC2 signalling controls plant development," Nature, Nature, vol. 609(7929), pages 986-993, September.
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