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Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

Author

Listed:
  • Federico Torta

    (National University of Singapore
    National University of Singapore
    Duke-National University of Singapore (NUS) Medical School)

  • Nils Hoffmann

    (Forschungszentrum Jülich GmbH
    University of Vienna)

  • Bo Burla

    (National University of Singapore)

  • Irina Alecu

    (University of Ottawa)

  • Makoto Arita

    (RIKEN Center for Integrative Medical Sciences
    Yokohama City University)

  • Takeshi Bamba

    (Kyushu University)

  • Steffany A. L. Bennett

    (University of Ottawa)

  • Justine Bertrand-Michel

    (MetaboHUBMetaToul Facility)

  • Britta Brügger

    (Heidelberg University Biochemistry Center (BZH))

  • Mónica P. Cala

    (Universidad de los Andes)

  • Dolores Camacho-Muñoz

    (Manchester Academic Health Science Centre)

  • Antonio Checa

    (Karolinska Institutet)

  • Michael Chen

    (University of British Columbia)

  • Michaela Chocholoušková

    (University of Pardubice)

  • Michelle Cinel

    (Baker Heart and Diabetes Institute
    La Trobe University)

  • Emeline Chu-Van

    (MetaboHUB)

  • Benoit Colsch

    (MetaboHUB)

  • Cristina Coman

    (University of Vienna)

  • Lisa Connell

    (Avanti Polar Lipids)

  • Bebiana C. Sousa

    (Babraham Research Campus)

  • Alex M. Dickens

    (University of Turku and Åbo Akademi University
    University of Turku)

  • Maria Fedorova

    (University of Leipzig
    University of Leipzig
    Faculty of Medicine Carl Gustav Carus of TU Dresden)

  • Finnur Freyr Eiríksson

    (University of Iceland
    ArcticMass)

  • Hector Gallart-Ayala

    (University of Lausanne)

  • Mohan Ghorasaini

    (Leiden University Medical Center)

  • Martin Giera

    (Leiden University Medical Center)

  • Xue Li Guan

    (Nanyang Technological University)

  • Mark Haid

    (German Research Center for Environmental Health)

  • Thomas Hankemeier

    (Leiden University)

  • Amy Harms

    (Leiden University)

  • Marcus Höring

    (Institute of Clinical Chemistry and Laboratory Medicine)

  • Michal Holčapek

    (University of Pardubice)

  • Thorsten Hornemann

    (University Zurich)

  • Chunxiu Hu

    (Chinese Academy of Sciences)

  • Andreas J. Hülsmeier

    (University Zurich)

  • Kevin Huynh

    (Baker Heart and Diabetes Institute
    La Trobe University)

  • Christina M. Jones

    (National Institute of Standards and Technology)

  • Julijana Ivanisevic

    (University of Lausanne)

  • Yoshihiro Izumi

    (Kyushu University)

  • Harald C. Köfeler

    (Medical University of Graz)

  • Sin Man Lam

    (LipidALL Technologies
    Chinese Academy of Sciences)

  • Mike Lange

    (University of Leipzig
    University of Leipzig)

  • Jong Cheol Lee

    (Yonsei University)

  • Gerhard Liebisch

    (Institute of Clinical Chemistry and Laboratory Medicine)

  • Katrice Lippa

    (National Institute of Standards and Technology)

  • Andrea F. Lopez-Clavijo

    (Babraham Research Campus)

  • Malena Manzi

    (Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
    Intendente Güiraldes
    Instituto Nacional de Tecnología Industrial)

  • Manuela R. Martinefski

    (Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
    Departamento de Ciencias Químicas)

  • Raviswamy G. H. Math

    (Tata Institute of Fundamental Research)

  • Satyajit Mayor

    (Tata Institute of Fundamental Research)

  • Peter J. Meikle

    (Baker Heart and Diabetes Institute
    La Trobe University)

  • María Eugenia Monge

    (Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET))

  • Myeong Hee Moon

    (Yonsei University)

  • Sneha Muralidharan

    (National University of Singapore
    Tata Institute of Fundamental Research)

  • Anna Nicolaou

    (Manchester Academic Health Science Centre
    Manchester Academic Health Science Centre)

  • Thao Nguyen-Tran

    (University of Ottawa)

  • Valerie B. O’Donnell

    (Cardiff University)

  • Matej Orešič

    (University of Turku and Åbo Akademi University
    Örebro University)

  • Arvind Ramanathan

    (Institute for Stem Cell Science and Regenerative Medicine)

  • Fabien Riols

    (German Research Center for Environmental Health)

  • Daisuke Saigusa

    (Teikyo University
    Tohoku University)

  • Tracey B. Schock

    (National Institute of Standards and Technology)

  • Heidi Schwartz-Zimmermann

    (Vienna (BOKU))

  • Guanghou Shui

    (Chinese Academy of Sciences)

  • Madhulika Singh

    (Leiden University)

  • Masatomo Takahashi

    (Kyushu University)

  • Margrét Thorsteinsdóttir

    (University of Iceland
    ArcticMass)

  • Noriyuki Tomiyasu

    (Kyushu University)

  • Anthony Tournadre

    (MetaboHUBMetaToul Facility)

  • Hiroshi Tsugawa

    (RIKEN Center for Integrative Medical Sciences
    Yokohama City University
    RIKEN Center for Sustainable Resource Science
    Tokyo University of Agriculture and Technology)

  • Victoria J. Tyrrell

    (Cardiff University)

  • Grace Gugten

    (Department of Pathology and Laboratory Medicine)

  • Michael O. Wakelam

    (Babraham Research Campus)

  • Craig E. Wheelock

    (Karolinska Institutet
    Karolinska University Hospital)

  • Denise Wolrab

    (University of Pardubice)

  • Guowang Xu

    (Chinese Academy of Sciences)

  • Tianrun Xu

    (Chinese Academy of Sciences)

  • John A. Bowden

    (University of Florida)

  • Kim Ekroos

    (Lipidomics Consulting Ltd.)

  • Robert Ahrends

    (University of Vienna)

  • Markus R. Wenk

    (National University of Singapore
    National University of Singapore
    Hamad Bin Khalifa University)

Abstract

In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (National Institute of Standards and Technology) human blood plasma Standard Reference Material (SRM) 1950, as well as a set of candidate plasma reference materials (RM 8231). Participants either utilized a provided validated method and/or their method of choice. Mean concentration values, and intra- and inter-laboratory coefficients of variation (CV) were calculated using single-point and multi-point calibrations, respectively. These results are the most precise (intra-laboratory CVs ≤ 4.2%) and concordant (inter-laboratory CVs

Suggested Citation

  • Federico Torta & Nils Hoffmann & Bo Burla & Irina Alecu & Makoto Arita & Takeshi Bamba & Steffany A. L. Bennett & Justine Bertrand-Michel & Britta Brügger & Mónica P. Cala & Dolores Camacho-Muñoz & An, 2024. "Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52087-x
    DOI: 10.1038/s41467-024-52087-x
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    References listed on IDEAS

    as
    1. Rubina Tabassum & Joel T. Rämö & Pietari Ripatti & Jukka T. Koskela & Mitja Kurki & Juha Karjalainen & Priit Palta & Shabbeer Hassan & Javier Nunez-Fontarnau & Tuomo T. J. Kiiskinen & Sanni Söderlund , 2019. "Genetic architecture of human plasma lipidome and its link to cardiovascular disease," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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