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Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Author

Listed:
  • Rubina Tabassum

    (HiLIFE, University of Helsinki)

  • Joel T. Rämö

    (HiLIFE, University of Helsinki)

  • Pietari Ripatti

    (HiLIFE, University of Helsinki)

  • Jukka T. Koskela

    (HiLIFE, University of Helsinki)

  • Mitja Kurki

    (HiLIFE, University of Helsinki
    Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Juha Karjalainen

    (HiLIFE, University of Helsinki
    Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital and Harvard Medical School)

  • Priit Palta

    (HiLIFE, University of Helsinki
    University of Tartu)

  • Shabbeer Hassan

    (HiLIFE, University of Helsinki)

  • Javier Nunez-Fontarnau

    (HiLIFE, University of Helsinki)

  • Tuomo T. J. Kiiskinen

    (HiLIFE, University of Helsinki
    National Institute for Health and Welfare)

  • Sanni Söderlund

    (Helsinki University Hospital)

  • Niina Matikainen

    (Helsinki University Hospital
    Helsinki University Hospital)

  • Mathias J. Gerl

    (Lipotype GmbH)

  • Michal A. Surma

    (Lipotype GmbH
    Łukasiewicz Research Network-PORT Polish Center for Technology Development)

  • Christian Klose

    (Lipotype GmbH)

  • Nathan O. Stitziel

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

  • Hannele Laivuori

    (HiLIFE, University of Helsinki
    Faculty of Medicine and Health Technology
    University of Helsinki and Helsinki University Hospital)

  • Aki S. Havulinna

    (HiLIFE, University of Helsinki
    National Institute for Health and Welfare)

  • Susan K. Service

    (University of California)

  • Veikko Salomaa

    (National Institute for Health and Welfare)

  • Matti Pirinen

    (HiLIFE, University of Helsinki
    University of Helsinki
    University of Helsinki)

  • Matti Jauhiainen

    (National Institute for Health and Welfare
    Minerva Foundation Institute for Medical Research, Biomedicum)

  • Mark J. Daly

    (HiLIFE, University of Helsinki
    Broad Institute of the Massachusetts Institute of Technology and Harvard University)

  • Nelson B. Freimer

    (University of California)

  • Aarno Palotie

    (HiLIFE, University of Helsinki
    Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Medicine, and the Department of Neurology, Massachusetts General Hospital)

  • Marja-Riitta Taskinen

    (Helsinki University Hospital)

  • Kai Simons

    (Lipotype GmbH
    Max Planck Institute of Molecular Cell Biology and Genetics)

  • Samuli Ripatti

    (HiLIFE, University of Helsinki
    Broad Institute of the Massachusetts Institute of Technology and Harvard University
    University of Helsinki)

Abstract

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P

Suggested Citation

  • Rubina Tabassum & Joel T. Rämö & Pietari Ripatti & Jukka T. Koskela & Mitja Kurki & Juha Karjalainen & Priit Palta & Shabbeer Hassan & Javier Nunez-Fontarnau & Tuomo T. J. Kiiskinen & Sanni Söderlund , 2019. "Genetic architecture of human plasma lipidome and its link to cardiovascular disease," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11954-8
    DOI: 10.1038/s41467-019-11954-8
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    Citations

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    Cited by:

    1. Federico Torta & Nils Hoffmann & Bo Burla & Irina Alecu & Makoto Arita & Takeshi Bamba & Steffany A. L. Bennett & Justine Bertrand-Michel & Britta Brügger & Mónica P. Cala & Dolores Camacho-Muñoz & An, 2024. "Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Linda Ottensmann & Rubina Tabassum & Sanni E. Ruotsalainen & Mathias J. Gerl & Christian Klose & Elisabeth Widén & Kai Simons & Samuli Ripatti & Matti Pirinen, 2023. "Genome-wide association analysis of plasma lipidome identifies 495 genetic associations," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Gemma Cadby & Corey Giles & Phillip E. Melton & Kevin Huynh & Natalie A. Mellett & Thy Duong & Anh Nguyen & Michelle Cinel & Alex Smith & Gavriel Olshansky & Tingting Wang & Marta Brozynska & Mike Ino, 2022. "Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Raissa Lerner & Dhanwin Baker & Claudia Schwitter & Sarah Neuhaus & Tony Hauptmann & Julia M. Post & Stefan Kramer & Laura Bindila, 2023. "Four-dimensional trapped ion mobility spectrometry lipidomics for high throughput clinical profiling of human blood samples," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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