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Hypothalamic-hindbrain circuit for consumption-induced fear regulation

Author

Listed:
  • Qin Wang

    (Zhejiang University School of Medicine)

  • Rui-Yue Sun

    (Zhejiang University School of Medicine)

  • Jia-Xue Hu

    (Zhejiang University School of Medicine)

  • Yan-Hui Sun

    (Zhejiang University School of Medicine)

  • Chun-Yue Li

    (Zhejiang University School of Medicine)

  • Huiqian Huang

    (Zhejiang University School of Medicine)

  • Hao Wang

    (Zhejiang University School of Medicine
    Nanhu Brain-computer Interface Institute
    Zhejiang University School of Medicine)

  • Xiao-Ming Li

    (Zhejiang University School of Medicine
    Nanhu Brain-computer Interface Institute
    Zhejiang University
    Chinese Academy of Medical Sciences)

Abstract

To ensure survival, animals must sometimes suppress fear responses triggered by potential threats during feeding. However, the mechanisms underlying this process remain poorly understood. In the current study, we demonstrated that when fear-conditioned stimuli (CS) were presented during food consumption, a neural projection from lateral hypothalamic (LH) GAD2 neurons to nucleus incertus (NI) relaxin-3 (RLN3)-expressing neurons was activated, leading to a reduction in CS-induced freezing behavior in male mice. LHGAD2 neurons established excitatory connections with the NI. The activity of this neural circuit, including NIRLN3 neurons, attenuated CS-induced freezing responses during food consumption. Additionally, the lateral mammillary nucleus (LM), which received NIRLN3 projections, along with RLN3 signaling in the LM, mediated the decrease in freezing behavior. Collectively, this study identified an LHGAD2-NIRLN3-LM circuit involved in modulating fear responses during feeding, thereby enhancing our understanding of how animals coordinate nutrient intake with threat avoidance.

Suggested Citation

  • Qin Wang & Rui-Yue Sun & Jia-Xue Hu & Yan-Hui Sun & Chun-Yue Li & Huiqian Huang & Hao Wang & Xiao-Ming Li, 2024. "Hypothalamic-hindbrain circuit for consumption-induced fear regulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51983-6
    DOI: 10.1038/s41467-024-51983-6
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