IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-51053-x.html
   My bibliography  Save this article

Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population

Author

Listed:
  • Lenka Stejskal

    (Manchester Academic Health Science Centre, The University of Manchester)

  • Angela Thistlethwaite

    (Manchester Academic Health Science Centre, The University of Manchester)

  • Fidel Ramirez-Bencomo

    (Manchester Academic Health Science Centre, The University of Manchester)

  • Smruti Rashmi

    (Manchester Academic Health Science Centre, The University of Manchester)

  • Odile Harrison

    (University of Oxford)

  • Ian M. Feavers

    (11a Mansfield Road, University of Oxford)

  • Martin C. J. Maiden

    (11a Mansfield Road, University of Oxford)

  • Ann Jerse

    (Uniformed Services University, 4301 Jones Bridge Road)

  • Grace Barnes

    (University of Oxford, South Parks Road)

  • Oscar Chirro

    (KEMRI-Wellcome Trust Research Programme)

  • James Chemweno

    (KEMRI-Wellcome Trust Research Programme)

  • Eunice Nduati

    (KEMRI-Wellcome Trust Research Programme)

  • Ana Cehovin

    (University of Oxford, South Parks Road)

  • Christoph Tang

    (University of Oxford, South Parks Road)

  • Eduard J. Sanders

    (The Aurum Institute)

  • Jeremy P. Derrick

    (Manchester Academic Health Science Centre, The University of Manchester)

Abstract

Development of a vaccine against gonorrhoea is a global priority, driven by the rise in antibiotic resistance. Although Neisseria gonorrhoeae (Ng) infection does not induce substantial protective immunity, highly exposed individuals may develop immunity against re-infection with the same strain. Retrospective epidemiological studies have shown that vaccines containing Neisseria meningitidis (Nm) outer membrane vesicles (OMVs) provide a degree of cross-protection against Ng infection. We conducted a clinical trial (NCT04297436) of 4CMenB (Bexsero, GSK), a licensed Nm vaccine containing OMVs and recombinant antigens, comprising a single arm, open label study of two doses with 50 adults in coastal Kenya who have high exposure to Ng. Data from a Ng antigen microarray established that serum IgG and IgA reactivities against the gonococcal homologs of the recombinant antigens in the vaccine peaked at 10 but had declined by 24 weeks. For most reactive OMV-derived antigens, the reverse was the case. A cohort of similar individuals with laboratory-confirmed gonococcal infection were compared before, during, and after infection: their reactivities were weaker and differed from the vaccinated cohort. We conclude that the cross-protection of the 4CMenB vaccine against gonorrhoea could be explained by cross-reaction against a diverse selection of antigens derived from the OMV component.

Suggested Citation

  • Lenka Stejskal & Angela Thistlethwaite & Fidel Ramirez-Bencomo & Smruti Rashmi & Odile Harrison & Ian M. Feavers & Martin C. J. Maiden & Ann Jerse & Grace Barnes & Oscar Chirro & James Chemweno & Euni, 2024. "Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51053-x
    DOI: 10.1038/s41467-024-51053-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-51053-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-51053-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hai Li & Julien P. Limenitakis & Victor Greiff & Bahtiyar Yilmaz & Olivier Schären & Camilla Urbaniak & Mirjam Zünd & Melissa A. E. Lawson & Ian D. Young & Sandra Rupp & Mathias Heikenwälder & Kathy D, 2020. "Mucosal or systemic microbiota exposures shape the B cell repertoire," Nature, Nature, vol. 584(7820), pages 274-278, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Cyril Planchais & Luis M. Molinos-Albert & Pierre Rosenbaum & Thierry Hieu & Alexia Kanyavuz & Dominique Clermont & Thierry Prazuck & Laurent Lefrou & Jordan D. Dimitrov & Sophie Hüe & Laurent Hocquel, 2023. "HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Emma M. Koff & Debbie Baarle & Marlies A. Houten & Marta Reyman & Guy A. M. Berbers & Femke Ham & Mei Ling J. N. Chu & Elisabeth A. M. Sanders & Debby Bogaert & Susana Fuentes, 2022. "Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51053-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.