IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-34155-2.html
   My bibliography  Save this article

Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination

Author

Listed:
  • Emma M. Koff

    (Spaarne Academy, Spaarne Gasthuis
    Wilhelmina Children’s Hospital and University Medical Centre Utrecht
    Amsterdam University Medical Centre)

  • Debbie Baarle

    (National Institute for Public Health and the Environment
    Virology and Immunology research Group, University Medical Centre Groningen)

  • Marlies A. Houten

    (Spaarne Academy, Spaarne Gasthuis
    Spaarne Gasthuis)

  • Marta Reyman

    (Wilhelmina Children’s Hospital and University Medical Centre Utrecht
    Erasmus University Medical Centre)

  • Guy A. M. Berbers

    (National Institute for Public Health and the Environment)

  • Femke Ham

    (National Institute for Public Health and the Environment)

  • Mei Ling J. N. Chu

    (Wilhelmina Children’s Hospital and University Medical Centre Utrecht
    National Institute for Public Health and the Environment)

  • Elisabeth A. M. Sanders

    (Wilhelmina Children’s Hospital and University Medical Centre Utrecht
    National Institute for Public Health and the Environment)

  • Debby Bogaert

    (Wilhelmina Children’s Hospital and University Medical Centre Utrecht
    National Institute for Public Health and the Environment
    University of Edinburgh)

  • Susana Fuentes

    (National Institute for Public Health and the Environment)

Abstract

The gut microbiota in early life, when critical immune maturation takes place, may influence the immunogenicity of childhood vaccinations. Here we assess the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific antibody responses against pneumococcal vaccination in 101 infants at age 12 months and against meningococcal vaccination in 66 infants at age 18 months. Birth by vaginal delivery is associated with higher antibody responses against both vaccines. Relative abundances of vaginal birth-associated Bifidobacterium and Escherichia coli in the first weeks of life are positively associated with anti-pneumococcal antibody responses, and relative abundance of E. coli in the same period is also positively associated with anti-meningococcal antibody responses. In this study, we show that mode of delivery-induced microbiota profiles of the gut are associated with subsequent antibody responses to routine childhood vaccines.

Suggested Citation

  • Emma M. Koff & Debbie Baarle & Marlies A. Houten & Marta Reyman & Guy A. M. Berbers & Femke Ham & Mei Ling J. N. Chu & Elisabeth A. M. Sanders & Debby Bogaert & Susana Fuentes, 2022. "Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34155-2
    DOI: 10.1038/s41467-022-34155-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-34155-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-34155-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ian Holmes & Keith Harris & Christopher Quince, 2012. "Dirichlet Multinomial Mixtures: Generative Models for Microbial Metagenomics," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-15, February.
    2. Hai Li & Julien P. Limenitakis & Victor Greiff & Bahtiyar Yilmaz & Olivier Schären & Camilla Urbaniak & Mirjam Zünd & Melissa A. E. Lawson & Ian D. Young & Sandra Rupp & Mathias Heikenwälder & Kathy D, 2020. "Mucosal or systemic microbiota exposures shape the B cell repertoire," Nature, Nature, vol. 584(7820), pages 274-278, August.
    3. Christopher J. Stewart & Nadim J. Ajami & Jacqueline L. O’Brien & Diane S. Hutchinson & Daniel P. Smith & Matthew C. Wong & Matthew C. Ross & Richard E. Lloyd & HarshaVardhan Doddapaneni & Ginger A. M, 2018. "Temporal development of the gut microbiome in early childhood from the TEDDY study," Nature, Nature, vol. 562(7728), pages 583-588, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Julien Tap & Franck Lejzerowicz & Aurélie Cotillard & Matthieu Pichaud & Daniel McDonald & Se Jin Song & Rob Knight & Patrick Veiga & Muriel Derrien, 2023. "Global branches and local states of the human gut microbiome define associations with environmental and intrinsic factors," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Ruairi C. Robertson & Thaddeus J. Edens & Lynnea Carr & Kuda Mutasa & Ethan K. Gough & Ceri Evans & Hyun Min Geum & Iman Baharmand & Sandeep K. Gill & Robert Ntozini & Laura E. Smith & Bernard Chasekw, 2023. "The gut microbiome and early-life growth in a population with high prevalence of stunting," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Achal Dhariwal & Polona Rajar & Gabriela Salvadori & Heidi Aarø Åmdal & Dag Berild & Ola Didrik Saugstad & Drude Fugelseth & Gorm Greisen & Ulf Dahle & Kirsti Haaland & Fernanda Cristina Petersen, 2024. "Prolonged hospitalization signature and early antibiotic effects on the nasopharyngeal resistome in preterm infants," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Cyril Planchais & Luis M. Molinos-Albert & Pierre Rosenbaum & Thierry Hieu & Alexia Kanyavuz & Dominique Clermont & Thierry Prazuck & Laurent Lefrou & Jordan D. Dimitrov & Sophie Hüe & Laurent Hocquel, 2023. "HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Laura Anderlucci & Cinzia Viroli, 2020. "Mixtures of Dirichlet-Multinomial distributions for supervised and unsupervised classification of short text data," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 14(4), pages 759-770, December.
    6. Li Zhang & Karen R. Jonscher & Zuyuan Zhang & Yi Xiong & Ryan S. Mueller & Jacob E. Friedman & Chongle Pan, 2022. "Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Sanzhima Garmaeva & Trishla Sinha & Anastasia Gulyaeva & Nataliia Kuzub & Johanne E. Spreckels & Sergio Andreu-Sánchez & Ranko Gacesa & Arnau Vich Vila & Siobhan Brushett & Marloes Kruk & Jackie Deken, 2024. "Transmission and dynamics of mother-infant gut viruses during pregnancy and early life," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Sanjeena Subedi & Drew Neish & Stephen Bak & Zeny Feng, 2020. "Cluster analysis of microbiome data by using mixtures of Dirichlet–multinomial regression models," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 69(5), pages 1163-1187, November.
    9. Fanette Fontaine & Sondra Turjeman & Karel Callens & Omry Koren, 2023. "The intersection of undernutrition, microbiome, and child development in the first years of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    10. Zhao, Xin & Zhang, Jingru & Lin, Wei, 2023. "Clustering multivariate count data via Dirichlet-multinomial network fusion," Computational Statistics & Data Analysis, Elsevier, vol. 179(C).
    11. Yaru Song & Hongyu Zhao & Tao Wang, 2020. "An adaptive independence test for microbiome community data," Biometrics, The International Biometric Society, vol. 76(2), pages 414-426, June.
    12. Pratheepa Jeganathan & Susan P. Holmes, 2021. "A Statistical Perspective on the Challenges in Molecular Microbial Biology," Journal of Agricultural, Biological and Environmental Statistics, Springer;The International Biometric Society;American Statistical Association, vol. 26(2), pages 131-160, June.
    13. Ana Popovic & Celine Bourdon & Pauline W. Wang & David S. Guttman & Sajid Soofi & Zulfiqar A. Bhutta & Robert H. J. Bandsma & John Parkinson & Lisa G. Pell, 2021. "Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    14. Alice Risely & Kerstin Wilhelm & Tim Clutton-Brock & Marta B. Manser & Simone Sommer, 2021. "Diurnal oscillations in gut bacterial load and composition eclipse seasonal and lifetime dynamics in wild meerkats," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    15. Shaikh Mateen R. & Beyene Joseph, 2017. "Statistical models and computational algorithms for discovering relationships in microbiome data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 16(1), pages 1-12, March.
    16. Georgios D. Kitsios & Khaled Sayed & Adam Fitch & Haopu Yang & Noel Britton & Faraaz Shah & William Bain & John W. Evankovich & Shulin Qin & Xiaohong Wang & Kelvin Li & Asha Patel & Yingze Zhang & Jos, 2024. "Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    17. Suzanne L. Ishaq & Emily F. Wissel & Patricia G. Wolf & Laura Grieneisen & Erin M. Eggleston & Gwynne Mhuireach & Michael Friedman & Anne Lichtenwalner & Jessica Otero Machuca & Katherine Weatherford , 2022. "Designing the Microbes and Social Equity Symposium: A Novel Interdisciplinary Virtual Research Conference Based on Achieving Group-Directed Outputs," Challenges, MDPI, vol. 13(2), pages 1-20, July.
    18. Justine Tanoey & Christina Baechle & Hermann Brenner & Andreas Deckert & Julia Fricke & Kathrin Günther & André Karch & Thomas Keil & Alexander Kluttig & Michael Leitzmann & Rafael Mikolajczyk & Nadia, 2022. "Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort," IJERPH, MDPI, vol. 19(17), pages 1-14, August.
    19. Yue Clare Lou & Benjamin E. Rubin & Marie C. Schoelmerich & Kaden S. DiMarco & Adair L. Borges & Rachel Rovinsky & Leo Song & Jennifer A. Doudna & Jillian F. Banfield, 2023. "Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2’-fucosyllactose utilization can be facilitated by coexisting species," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    20. Mishra, Aditya & Müller, Christian L., 2022. "Robust regression with compositional covariates," Computational Statistics & Data Analysis, Elsevier, vol. 165(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34155-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.