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Effect of pneumococcal conjugate vaccine six years post-introduction on pneumococcal carriage in Ulaanbaatar, Mongolia

Author

Listed:
  • Claire Mollendorf

    (Murdoch Children’s Research Institute
    The University of Melbourne)

  • Tuya Mungun

    (National Center of Communicable Diseases)

  • Munkhchuluun Ulziibayar

    (National Center of Communicable Diseases)

  • Paige Skoko

    (Murdoch Children’s Research Institute
    The University of Melbourne)

  • Laura Boelsen

    (Murdoch Children’s Research Institute)

  • Cattram Nguyen

    (Murdoch Children’s Research Institute
    The University of Melbourne)

  • Purevsuren Batsaikhan

    (National Center of Communicable Diseases)

  • Bujinlkham Suuri

    (National Center of Communicable Diseases)

  • Dashtseren Luvsantseren

    (National Center of Communicable Diseases)

  • Dorj Narangerel

    (Ministry of Health)

  • Bilegtsaikhan Tsolmon

    (National Center of Communicable Diseases
    Mongolian National University of Medical Sciences)

  • Sodbayar Demberelsuren

    (World Health Organization)

  • Belinda D. Ortika

    (Murdoch Children’s Research Institute)

  • Casey L. Pell

    (Murdoch Children’s Research Institute)

  • Ashleigh Wee-Hee

    (Murdoch Children’s Research Institute
    The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Monica L. Nation

    (Murdoch Children’s Research Institute)

  • Jason Hinds

    (University of London
    London Bioscience Innovation Centre)

  • Eileen M. Dunne

    (Murdoch Children’s Research Institute
    The University of Melbourne)

  • E. Kim Mulholland

    (Murdoch Children’s Research Institute
    The University of Melbourne
    London School of Hygiene and Tropical Medicine)

  • Catherine Satzke

    (Murdoch Children’s Research Institute
    The University of Melbourne
    The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

Abstract

Limited data from Asia are available on long-term effects of pneumococcal conjugate vaccine introduction on pneumococcal carriage. Here we assess the impact of 13-valent pneumococcal conjugate vaccine (PCV13) introduction on nasopharyngeal pneumococcal carriage prevalence, density and antimicrobial resistance. Cross-sectional carriage surveys were conducted pre-PCV13 (2015) and post-PCV13 introduction (2017 and 2022). Pneumococci were detected and quantified by real-time PCR from nasopharyngeal swabs. DNA microarray was used for molecular serotyping and to infer genetic lineage (Global Pneumococcal Sequence Cluster). The study included 1461 infants (5–8 weeks old) and 1489 toddlers (12–23 months old) enrolled from family health clinics. We show a reduction in PCV13 serotype carriage (with non-PCV13 serotype replacement) and a reduction in the proportion of samples containing resistance genes in toddlers six years post-PCV13 introduction. We observed an increase in pneumococcal nasopharyngeal density. Serotype 15 A, the most prevalent non-vaccine-serotype in 2022, was comprised predominantly of GPSC904;9. Reductions in PCV13 serotype carriage will likely result in pneumococcal disease reduction. It is important for ongoing surveillance to monitor serotype changes to potentially inform new vaccine development.

Suggested Citation

  • Claire Mollendorf & Tuya Mungun & Munkhchuluun Ulziibayar & Paige Skoko & Laura Boelsen & Cattram Nguyen & Purevsuren Batsaikhan & Bujinlkham Suuri & Dashtseren Luvsantseren & Dorj Narangerel & Bilegt, 2024. "Effect of pneumococcal conjugate vaccine six years post-introduction on pneumococcal carriage in Ulaanbaatar, Mongolia," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50944-3
    DOI: 10.1038/s41467-024-50944-3
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    References listed on IDEAS

    as
    1. Todd D. Swarthout & Claudio Fronterre & José Lourenço & Uri Obolski & Andrea Gori & Naor Bar-Zeev & Dean Everett & Arox W. Kamng’ona & Thandie S. Mwalukomo & Andrew A. Mataya & Charles Mwansambo & Mar, 2020. "High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    2. Alessandra Løchen & James E Truscott & Nicholas J Croucher, 2022. "Analysing pneumococcal invasiveness using Bayesian models of pathogen progression rates," PLOS Computational Biology, Public Library of Science, vol. 18(2), pages 1-37, February.
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