IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-36624-8.html
   My bibliography  Save this article

Optimal age targeting for pneumococcal vaccination in older adults; a modelling study

Author

Listed:
  • Deus Thindwa

    (London School of Hygiene & Tropical Medicine
    Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine
    Malawi Liverpool Wellcome Research Programme)

  • Samuel Clifford

    (London School of Hygiene & Tropical Medicine
    Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine)

  • Jackie Kleynhans

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Anne Gottberg

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Sibongile Walaza

    (National Institute for Communicable Diseases of the National Health Laboratory Service)

  • Susan Meiring

    (National Institute for Communicable Diseases of the National Health Laboratory Service)

  • Todd D. Swarthout

    (Malawi Liverpool Wellcome Research Programme
    University College London
    University Medical Centre Utrecht)

  • Elizabeth Miller

    (Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine)

  • Peter McIntyre

    (University of Otago)

  • Nick Andrews

    (UK Health Security Agency)

  • Zahin Amin-Chowdhury

    (UK Health Security Agency)

  • Norman Fry

    (UK Health Security Agency)

  • Kondwani C. Jambo

    (Malawi Liverpool Wellcome Research Programme
    Liverpool School of Tropical Medicine)

  • Neil French

    (Malawi Liverpool Wellcome Research Programme
    University of Liverpool)

  • Samanta Cristine Grassi Almeida

    (National Laboratory for Meningitis and Pneumococcal Infections, Laboratory for Meningitis, Pneumonia and Pneumococcal Infection, Centre of Bacteriology)

  • Shamez N. Ladhani

    (UK Health Security Agency)

  • Robert S. Heyderman

    (Malawi Liverpool Wellcome Research Programme
    University College London)

  • Cheryl Cohen

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Maria Cristina Cunto Brandileone

    (National Laboratory for Meningitis and Pneumococcal Infections, Laboratory for Meningitis, Pneumonia and Pneumococcal Infection, Centre of Bacteriology)

  • Stefan Flasche

    (London School of Hygiene & Tropical Medicine
    Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine)

Abstract

Invasive pneumococcal disease (IPD) risk increases with age for older adults whereas the population size benefiting from pneumococcal vaccines and robustness of immunogenic response to vaccination decline. We estimate how demographics, vaccine efficacy/effectiveness (VE), and waning VE impact on optimal age for a single-dose pneumococcal vaccination. Age- and vaccine-serotype-specific IPD cases from routine surveillance of adults ≥ 55 years old (y), ≥ 4-years after infant-pneumococcal vaccine introduction and before 2020, and VE data from prior studies were used to estimate IPD incidence and waning VE which were then combined in a cohort model of vaccine impact. In Brazil, Malawi, South Africa and England 51, 51, 54 and 39% of adults older than 55 y were younger than 65 years old, with a smaller share of annual IPD cases reported among

Suggested Citation

  • Deus Thindwa & Samuel Clifford & Jackie Kleynhans & Anne Gottberg & Sibongile Walaza & Susan Meiring & Todd D. Swarthout & Elizabeth Miller & Peter McIntyre & Nick Andrews & Zahin Amin-Chowdhury & Nor, 2023. "Optimal age targeting for pneumococcal vaccination in older adults; a modelling study," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36624-8
    DOI: 10.1038/s41467-023-36624-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-36624-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-36624-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Todd D. Swarthout & Claudio Fronterre & José Lourenço & Uri Obolski & Andrea Gori & Naor Bar-Zeev & Dean Everett & Arox W. Kamng’ona & Thandie S. Mwalukomo & Andrew A. Mataya & Charles Mwansambo & Mar, 2020. "High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Claire Mollendorf & Tuya Mungun & Munkhchuluun Ulziibayar & Paige Skoko & Laura Boelsen & Cattram Nguyen & Purevsuren Batsaikhan & Bujinlkham Suuri & Dashtseren Luvsantseren & Dorj Narangerel & Bilegt, 2024. "Effect of pneumococcal conjugate vaccine six years post-introduction on pneumococcal carriage in Ulaanbaatar, Mongolia," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Uri Obolski & Todd D. Swarthout & Akuzike Kalizang’oma & Thandie S. Mwalukomo & Jia Mun Chan & Caroline M. Weight & Comfort Brown & Rory Cave & Jen Cornick & Arox Wadson Kamng’ona & Jacquline Msefula , 2023. "The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36624-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.