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Optimal age targeting for pneumococcal vaccination in older adults; a modelling study

Author

Listed:
  • Deus Thindwa

    (London School of Hygiene & Tropical Medicine
    Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine
    Malawi Liverpool Wellcome Research Programme)

  • Samuel Clifford

    (London School of Hygiene & Tropical Medicine
    Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine)

  • Jackie Kleynhans

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Anne Gottberg

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Sibongile Walaza

    (National Institute for Communicable Diseases of the National Health Laboratory Service)

  • Susan Meiring

    (National Institute for Communicable Diseases of the National Health Laboratory Service)

  • Todd D. Swarthout

    (Malawi Liverpool Wellcome Research Programme
    University College London
    University Medical Centre Utrecht)

  • Elizabeth Miller

    (Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine)

  • Peter McIntyre

    (University of Otago)

  • Nick Andrews

    (UK Health Security Agency)

  • Zahin Amin-Chowdhury

    (UK Health Security Agency)

  • Norman Fry

    (UK Health Security Agency)

  • Kondwani C. Jambo

    (Malawi Liverpool Wellcome Research Programme
    Liverpool School of Tropical Medicine)

  • Neil French

    (Malawi Liverpool Wellcome Research Programme
    University of Liverpool)

  • Samanta Cristine Grassi Almeida

    (National Laboratory for Meningitis and Pneumococcal Infections, Laboratory for Meningitis, Pneumonia and Pneumococcal Infection, Centre of Bacteriology)

  • Shamez N. Ladhani

    (UK Health Security Agency)

  • Robert S. Heyderman

    (Malawi Liverpool Wellcome Research Programme
    University College London)

  • Cheryl Cohen

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Maria Cristina Cunto Brandileone

    (National Laboratory for Meningitis and Pneumococcal Infections, Laboratory for Meningitis, Pneumonia and Pneumococcal Infection, Centre of Bacteriology)

  • Stefan Flasche

    (London School of Hygiene & Tropical Medicine
    Department of Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine)

Abstract

Invasive pneumococcal disease (IPD) risk increases with age for older adults whereas the population size benefiting from pneumococcal vaccines and robustness of immunogenic response to vaccination decline. We estimate how demographics, vaccine efficacy/effectiveness (VE), and waning VE impact on optimal age for a single-dose pneumococcal vaccination. Age- and vaccine-serotype-specific IPD cases from routine surveillance of adults ≥ 55 years old (y), ≥ 4-years after infant-pneumococcal vaccine introduction and before 2020, and VE data from prior studies were used to estimate IPD incidence and waning VE which were then combined in a cohort model of vaccine impact. In Brazil, Malawi, South Africa and England 51, 51, 54 and 39% of adults older than 55 y were younger than 65 years old, with a smaller share of annual IPD cases reported among

Suggested Citation

  • Deus Thindwa & Samuel Clifford & Jackie Kleynhans & Anne Gottberg & Sibongile Walaza & Susan Meiring & Todd D. Swarthout & Elizabeth Miller & Peter McIntyre & Nick Andrews & Zahin Amin-Chowdhury & Nor, 2023. "Optimal age targeting for pneumococcal vaccination in older adults; a modelling study," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36624-8
    DOI: 10.1038/s41467-023-36624-8
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    References listed on IDEAS

    as
    1. Todd D. Swarthout & Claudio Fronterre & José Lourenço & Uri Obolski & Andrea Gori & Naor Bar-Zeev & Dean Everett & Arox W. Kamng’ona & Thandie S. Mwalukomo & Andrew A. Mataya & Charles Mwansambo & Mar, 2020. "High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

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