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Biocatalysis enables the scalable conversion of biobased furans into various furfurylamines

Author

Listed:
  • Pritam Giri

    (Konkuk University)

  • Seonga Lim

    (Konkuk University)

  • Taresh P. Khobragade

    (Konkuk University)

  • Amol D. Pagar

    (Konkuk University)

  • Mahesh D. Patil

    (CSIR- National Chemical Laboratory)

  • Sharad Sarak

    (Konkuk University)

  • Hyunwoo Jeon

    (Konkuk University)

  • Sangwoo Joo

    (Konkuk University)

  • Younghwan Goh

    (Konkuk University)

  • Seohee Jung

    (Konkuk University)

  • Yu-Jeong Jang

    (Konkuk University)

  • Seung Beom Choi

    (Konkuk University)

  • Ye Chan Kim

    (Seoul National University)

  • Taek Jin Kang

    (Dongguk University)

  • Yong-Seok Heo

    (Konkuk University)

  • Hyungdon Yun

    (Konkuk University)

Abstract

Biobased furans have emerged as chemical building blocks for the development of materials because of their diverse scaffolds and as they can be directly prepared from sugars. However, selective, efficient, and cost-effective scalable conversion of biobased furans remains elusive. Here, we report a robust transaminase (TA) from Shimia marina (SMTA) that enables the scalable amination of biobased furanaldehydes with high activity and broad substrate specificity. Crystallographic and mutagenesis analyses provide mechanistic insights and a structural basis for understanding SMTA, which enables a higher substrate conversion. The enzymatic cascade process established in this study allows one-pot synthesis of 2,5-bis(aminomethyl)furan (BAMF) and 5-(aminomethyl)furan-2-carboxylic acid from 5-hydroxymethylfurfural. The biosynthesis of various furfurylamines, including a one-pot cascade reaction for BAMF generation using whole cells, demonstrates their practical application in the pharmaceutical and polymer industries.

Suggested Citation

  • Pritam Giri & Seonga Lim & Taresh P. Khobragade & Amol D. Pagar & Mahesh D. Patil & Sharad Sarak & Hyunwoo Jeon & Sangwoo Joo & Younghwan Goh & Seohee Jung & Yu-Jeong Jang & Seung Beom Choi & Ye Chan , 2024. "Biocatalysis enables the scalable conversion of biobased furans into various furfurylamines," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50637-x
    DOI: 10.1038/s41467-024-50637-x
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    References listed on IDEAS

    as
    1. William R. Birmingham & Asbjørn Toftgaard Pedersen & Mafalda Dias Gomes & Mathias Bøje Madsen & Michael Breuer & John M. Woodley & Nicholas J. Turner, 2021. "Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Ammar Al-Shameri & Dominik L. Siebert & Samuel Sutiono & Lars Lauterbach & Volker Sieber, 2023. "Hydrogenase-based oxidative biocatalysis without oxygen," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
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