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A novel interface for cortical columnar neuromodulation with multipoint infrared neural stimulation

Author

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  • Feiyan Tian

    (School of Medicine, Zhejiang University
    Zhejiang University)

  • Ying Zhang

    (School of Medicine, Zhejiang University
    Zhejiang University)

  • Kenneth E. Schriver

    (School of Medicine, Zhejiang University
    Zhejiang University)

  • Jia Ming Hu

    (School of Medicine, Zhejiang University
    Zhejiang University)

  • Anna Wang Roe

    (School of Medicine, Zhejiang University
    Zhejiang University
    Zhejiang University
    Zhejiang University)

Abstract

Cutting edge advances in electrical visual cortical prosthetics have evoked perception of shapes, motion, and letters in the blind. Here, we present an alternative optical approach using pulsed infrared neural stimulation. To interface with dense arrays of cortical columns with submillimeter spatial precision, both linear array and 100-fiber bundle array optical fiber interfaces were devised. We deliver infrared stimulation through these arrays in anesthetized cat visual cortex and monitor effects by optical imaging in contralateral visual cortex. Infrared neural stimulation modulation of response to ongoing visual oriented gratings produce enhanced responses in orientation-matched domains and suppressed responses in non-matched domains, consistent with a known higher order integration mediated by callosal inputs. Controls include dynamically applied speeds, directions and patterns of multipoint stimulation. This provides groundwork for a distinct type of prosthetic targeted to maps of visual cortical columns.

Suggested Citation

  • Feiyan Tian & Ying Zhang & Kenneth E. Schriver & Jia Ming Hu & Anna Wang Roe, 2024. "A novel interface for cortical columnar neuromodulation with multipoint infrared neural stimulation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50375-0
    DOI: 10.1038/s41467-024-50375-0
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    References listed on IDEAS

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    1. Michael Plaksin & Eitan Kimmel & Shy Shoham, 2017. "Correspondence: Revisiting the theoretical cell membrane thermal capacitance response," Nature Communications, Nature, vol. 8(1), pages 1-2, December.
    2. Gregory C. DeAngelis & Bruce G. Cumming & William T. Newsome, 1998. "Cortical area MT and the perception of stereoscopic depth," Nature, Nature, vol. 394(6694), pages 677-680, August.
    3. Dirk Jancke & Frédéric Chavane & Shmuel Naaman & Amiram Grinvald, 2004. "Imaging cortical correlates of illusion in early visual cortex," Nature, Nature, vol. 428(6981), pages 423-426, March.
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