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Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice

Author

Listed:
  • Mylène Fefeu

    (Service Hospitalo-Universitaire de psychiatrie
    Global Health Department
    Université de Paris Cité)

  • Michael Blatzer

    (Global Health Department)

  • Anita Kneppers

    (Univ Lyon)

  • David Briand

    (Global Health Department)

  • Pierre Rocheteau

    (Global Health Department)

  • Alexandre Haroche

    (Service Hospitalo-Universitaire de psychiatrie)

  • David Hardy

    (Global Health Department)

  • Mélanie Juchet-Martin

    (Global Health Department)

  • Anne Danckaert

    (UTechS PBI)

  • François Coudoré

    (Université Paris-Saclay)

  • Abdulkarim Tutakhail

    (Université Paris-Saclay)

  • Corinne Huchet

    (CHU Nantes)

  • Aude Lafoux

    (IRS 2 Nantes Biotech)

  • Rémi Mounier

    (Univ Lyon)

  • Olivier Mir

    (Gustave Roussy)

  • Raphaël Gaillard

    (Service Hospitalo-Universitaire de psychiatrie
    Global Health Department
    Université de Paris Cité)

  • Fabrice Chrétien

    (Global Health Department
    Université de Paris Cité
    Service Hospitalo-Universitaire de neuropathologie)

Abstract

Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigated whether fluoxetine could have broader peripheral regenerative properties. Following prolonged administration of fluoxetine in male mice, we showed that fluoxetine increases the number of muscle stem cells and muscle angiogenesis, associated with positive changes in skeletal muscle function. Fluoxetine also improved skeletal muscle regeneration after single and multiples injuries with an increased muscle stem cells pool and vessel density associated with reduced fibrotic lesions and inflammation. Mice devoid of peripheral serotonin treated with fluoxetine did not exhibit beneficial effects during muscle regeneration. Specifically, pharmacological, and genetic inactivation of the 5-HT1B subtype serotonin receptor also abolished the enhanced regenerative process induced by fluoxetine. We highlight here a regenerative property of serotonin on skeletal muscle.

Suggested Citation

  • Mylène Fefeu & Michael Blatzer & Anita Kneppers & David Briand & Pierre Rocheteau & Alexandre Haroche & David Hardy & Mélanie Juchet-Martin & Anne Danckaert & François Coudoré & Abdulkarim Tutakhail &, 2024. "Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50220-4
    DOI: 10.1038/s41467-024-50220-4
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    References listed on IDEAS

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    1. Mathilde Latil & Pierre Rocheteau & Laurent Châtre & Serena Sanulli & Sylvie Mémet & Miria Ricchetti & Shahragim Tajbakhsh & Fabrice Chrétien, 2012. "Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity," Nature Communications, Nature, vol. 3(1), pages 1-12, January.
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