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Barbed arrow-like structure membrane with ultra-high rectification coefficient enables ultra-fast, highly-sensitive lateral-flow assay of cTnI

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  • Juanhua Li

    (Shenzhen Campus of Sun Yat-sen University
    Sun Yat-sen University)

  • Yiren Liu

    (Shenzhen Campus of Sun Yat-sen University
    Sun Yat-sen University)

  • Tianyu Wu

    (Shenzhen Campus of Sun Yat-sen University
    Sun Yat-sen University)

  • Zihan Xiao

    (Shenzhen Campus of Sun Yat-sen University
    Sun Yat-sen University)

  • Jianhang Du

    (the Eighth Affiliated Hospital of Sun Yat-sen University)

  • Hongrui Liang

    (Shenzhen Campus of Sun Yat-sen University
    Sun Yat-sen University)

  • Cuiping Zhou

    (Southern Medical University)

  • Jianhua Zhou

    (Shenzhen Campus of Sun Yat-sen University
    Sun Yat-sen University)

Abstract

Acute myocardial infarction (AMI) has become a public health disease threatening public life safety due to its high mortality. The lateral-flow assay (LFA) of a typical cardiac biomarker, troponin I (cTnI), is essential for the timely warnings of AMI. However, it is a challenge to achieve an ultra-fast and highly-sensitive assay for cTnI (hs-cTnI) using current LFA, due to the limited performance of chromatographic membranes. Here, we propose a barbed arrow-like structure membrane (BAS Mem), which enables the unidirectional, fast flow and low-residual of liquid. The liquid is rectified through the forces generated by the sidewalls of the barbed arrow-like grooves. The rectification coefficient of liquid flow on BAS Mem is 14.5 (highest to date). Using BAS Mem to replace the conventional chromatographic membrane, we prepare batches of lateral-flow strips and achieve LFA of cTnI within 240 s, with a limit of detection of 1.97 ng mL−1. The lateral-flow strips exhibit a specificity of 100%, a sensitivity of 93.3% in detecting 25 samples of suspected AMI patients. The lateral-flow strips show great performance in providing reliable results for clinical diagnosis, with the potential to provide early warnings for AMI.

Suggested Citation

  • Juanhua Li & Yiren Liu & Tianyu Wu & Zihan Xiao & Jianhang Du & Hongrui Liang & Cuiping Zhou & Jianhua Zhou, 2024. "Barbed arrow-like structure membrane with ultra-high rectification coefficient enables ultra-fast, highly-sensitive lateral-flow assay of cTnI," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49810-z
    DOI: 10.1038/s41467-024-49810-z
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    References listed on IDEAS

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    1. Huawei Chen & Pengfei Zhang & Liwen Zhang & Hongliang Liu & Ying Jiang & Deyuan Zhang & Zhiwu Han & Lei Jiang, 2016. "Continuous directional water transport on the peristome surface of Nepenthes alata," Nature, Nature, vol. 532(7597), pages 85-89, April.
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