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COVID-19 vaccination and major cardiovascular and haematological adverse events in Abu Dhabi: retrospective cohort study

Author

Listed:
  • Marco A. F. Pimentel

    (M42)

  • Maaz Shaikh

    (M42)

  • Muna Al Safi

    (Department of Health (DOH))

  • Yousuf Naqvi

    (Department of Health (DOH))

  • Shadab Khan

    (M42)

Abstract

The widespread administration of COVID-19 vaccines has prompted a need to understand their safety profile. This investigation focuses on the safety of inactivated and mRNA-based COVID-19 vaccines, particularly concerning potential cardiovascular and haematological adverse events. A retrospective cohort study was conducted for 1.3 million individuals residing in Abu Dhabi, United Arab Emirates, who received 1.8 million doses of the inactivated BBIBP CorV (by SinoPharm) and mRNA-based BNT162b2 (Pfizer-BioNTech) vaccines between June 1, 2021, and June 30, 2022. The study’s primary outcome was to assess the occurrence of selected cardiovascular and haematological events leading to hospitalization or emergency room visits within 21 days post-vaccination. Results showed no significant increase in the incidence rates of these events compared to the subsequent 22 to 42 days following vaccination. Analysis revealed no elevated risk for adverse outcomes following first (IRR 1·03; 95% CI 0·82-1·31), second (IRR 0·92; 95% CI 0·72-1·16) and third (IRR 0·82; 95% CI 0·66-1·00) doses of either vaccine. This study found no substantial link between receiving either mRNA and inactivated COVID-19 vaccines and a higher likelihood of cardiovascular or haematological events within 21 days after vaccination.

Suggested Citation

  • Marco A. F. Pimentel & Maaz Shaikh & Muna Al Safi & Yousuf Naqvi & Shadab Khan, 2024. "COVID-19 vaccination and major cardiovascular and haematological adverse events in Abu Dhabi: retrospective cohort study," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49744-6
    DOI: 10.1038/s41467-024-49744-6
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    References listed on IDEAS

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    1. Stéphane Vu & Marion Bertrand & Marie-Joelle Jabagi & Jérémie Botton & Jérôme Drouin & Bérangère Baricault & Alain Weill & Rosemary Dray-Spira & Mahmoud Zureik, 2022. "Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Nawal Al Kaabi & Abderrahim Oulhaj & Subhashini Ganesan & Farida Ismail Al Hosani & Omer Najim & Halah Ibrahim & Juan Acuna & Ahmed R. Alsuwaidi & Ashraf M. Kamour & Ashraf Alzaabi & Badreyya Ahmed Al, 2022. "Effectiveness of BBIBP-CorV vaccine against severe outcomes of COVID-19 in Abu Dhabi, United Arab Emirates," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
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