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LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

Author

Listed:
  • Ningning Wang

    (Nanjing Agricultural University)

  • Andres Merits

    (University of Tartu)

  • Michael Veit

    (Free University Berlin)

  • Laura Sandra Lello

    (University of Tartu)

  • Shuhan Kong

    (Nanjing Agricultural University)

  • Houqi Jiao

    (Nanjing Agricultural University)

  • Jie Chen

    (Nanjing Agricultural University)

  • Yu Wang

    (Nanjing Agricultural University)

  • Georgi Dobrikov

    (Bulgarian Academy of Sciences)

  • Félix A. Rey

    (CNRS UMR 3569, 25-28 Rue du Docteur Roux, 75724 Paris Cedex 15)

  • Shuo Su

    (Nanjing Agricultural University
    Nanjing Agricultural University)

Abstract

Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.

Suggested Citation

  • Ningning Wang & Andres Merits & Michael Veit & Laura Sandra Lello & Shuhan Kong & Houqi Jiao & Jie Chen & Yu Wang & Georgi Dobrikov & Félix A. Rey & Shuo Su, 2024. "LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy," Nature Communications, Nature, vol. 15(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49301-1
    DOI: 10.1038/s41467-024-49301-1
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    References listed on IDEAS

    as
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