IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-49050-1.html
   My bibliography  Save this article

Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis

Author

Listed:
  • One B. Dintwe

    (Fred Hutchinson Cancer Center
    Hutchinson Centre Research Institute of South Africa)

  • Lamar Ballweber Fleming

    (Fred Hutchinson Cancer Center)

  • Valentin Voillet

    (Fred Hutchinson Cancer Center
    Hutchinson Centre Research Institute of South Africa)

  • John McNevin

    (Fred Hutchinson Cancer Center)

  • Aaron Seese

    (Fred Hutchinson Cancer Center)

  • Anneta Naidoo

    (Hutchinson Centre Research Institute of South Africa)

  • Saleha Omarjee

    (Hutchinson Centre Research Institute of South Africa)

  • Linda-Gail Bekker

    (University of Cape Town)

  • James G. Kublin

    (Fred Hutchinson Cancer Center)

  • Stephen C. Rosa

    (Fred Hutchinson Cancer Center
    University of Washington School of Medicine)

  • Evan W. Newell

    (Fred Hutchinson Cancer Center)

  • Andrew Fiore-Gartland

    (Fred Hutchinson Cancer Center)

  • Erica Andersen-Nissen

    (Fred Hutchinson Cancer Center
    Hutchinson Centre Research Institute of South Africa)

  • M. Juliana McElrath

    (Fred Hutchinson Cancer Center
    University of Washington School of Medicine)

Abstract

A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M.tb). In a companion phase 1b trial, HVTN 602/Aeras A-042, we characterize in-depth the cellular responses to BCG revaccination or to a H4:IC31 vaccine boost to identify T cell subsets that could be responsible for the protection observed. High-dimensional clustering analysis of cells profiled using a 26-color flow cytometric panel show marked increases in five effector memory CD4+ T cell subpopulations (TEM) after BCG revaccination, two of which are highly polyfunctional. CITE-Seq single-cell analysis shows that the activated subsets include an abundant cluster of Th1 cells with migratory potential. Additionally, a small cluster of Th17 TEM cells induced by BCG revaccination expresses high levels of CD103; these may represent recirculating tissue-resident memory cells that could provide pulmonary immune protection. Together, these results identify unique populations of CD4+ T cells with potential to be immune correlates of protection conferred by BCG revaccination.

Suggested Citation

  • One B. Dintwe & Lamar Ballweber Fleming & Valentin Voillet & John McNevin & Aaron Seese & Anneta Naidoo & Saleha Omarjee & Linda-Gail Bekker & James G. Kublin & Stephen C. Rosa & Evan W. Newell & Andr, 2024. "Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49050-1
    DOI: 10.1038/s41467-024-49050-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-49050-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-49050-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Patricia A. Darrah & Joseph J. Zeppa & Pauline Maiello & Joshua A. Hackney & Marc H. Wadsworth & Travis K. Hughes & Supriya Pokkali & Phillip A. Swanson & Nicole L. Grant & Mark A. Rodgers & Megha Kam, 2020. "Prevention of tuberculosis in macaques after intravenous BCG immunization," Nature, Nature, vol. 577(7788), pages 95-102, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dennis Lapuente & Jana Fuchs & Jonas Willar & Ana Vieira Antão & Valentina Eberlein & Nadja Uhlig & Leila Issmail & Anna Schmidt & Friederike Oltmanns & Antonia Sophia Peter & Sandra Mueller-Schmucker, 2021. "Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Abigail R. Gress & Christine E. Ronayne & Joshua M. Thiede & David K. Meyerholz & Samuel Okurut & Julia Stumpf & Tailor V. Mathes & Kenneth Ssebambulidde & David B. Meya & Fiona V. Cresswell & David R, 2023. "Recently activated CD4 T cells in tuberculosis express OX40 as a target for host-directed immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Davide Pisu & Luana Johnston & Joshua T. Mattila & David G. Russell, 2024. "The frequency of CD38+ alveolar macrophages correlates with early control of M. tuberculosis in the murine lung," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Eduardo Moreo & Aitor Jarit-Cabanillas & Iñaki Robles-Vera & Santiago Uranga & Claudia Guerrero & Ana Belén Gómez & Pablo Mata-Martínez & Luna Minute & Miguel Araujo-Voces & María José Felgueres & Glo, 2023. "Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Richard F. Silver & Mei Xia & Chad E. Storer & Jessica R. Jarvela & Michelle C. Moyer & Azra Blazevic & David A. Stoeckel & Erin K. Rakey & Jan M. Tennant & Johannes B. Goll & Richard D. Head & Daniel, 2023. "Distinct gene expression signatures comparing latent tuberculosis infection with different routes of Bacillus Calmette-Guérin vaccination," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Venkata S. Bollimpelli & Pradeep B. J Reddy & Sailaja Gangadhara & Tysheena P. Charles & Samantha L. Burton & Gregory K. Tharp & Tiffany M. Styles & Celia C. Labranche & Justin C. Smith & Amit A. Upad, 2023. "Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Joshua S. Woodworth & Helena Strand Clemmensen & Hannah Battey & Karin Dijkman & Thomas Lindenstrøm & Raquel Salvador Laureano & Randy Taplitz & Jeffrey Morgan & Claus Aagaard & Ida Rosenkrands & Ceci, 2021. "A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    8. Atienza-Diez, Iker & Seoane, Luís F., 2023. "Long- and short-term effects of cross-immunity in epidemic dynamics," Chaos, Solitons & Fractals, Elsevier, vol. 174(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49050-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.