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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques

Author

Listed:
  • Venkata S. Bollimpelli

    (Emory National Primate Research Center, Emory University)

  • Pradeep B. J Reddy

    (Emory National Primate Research Center, Emory University)

  • Sailaja Gangadhara

    (Emory National Primate Research Center, Emory University)

  • Tysheena P. Charles

    (Emory National Primate Research Center, Emory University)

  • Samantha L. Burton

    (Emory National Primate Research Center, Emory University)

  • Gregory K. Tharp

    (Emory National Primate Research Center)

  • Tiffany M. Styles

    (Emory National Primate Research Center, Emory University)

  • Celia C. Labranche

    (Duke University School of Medicine)

  • Justin C. Smith

    (Louisiana State University Health Sciences Center)

  • Amit A. Upadhyay

    (Emory National Primate Research Center, Emory University)

  • Anusmita Sahoo

    (Emory National Primate Research Center, Emory University)

  • Traci Legere

    (Emory National Primate Research Center, Emory University)

  • Ayalnesh Shiferaw

    (Emory National Primate Research Center, Emory University)

  • Vijayakumar Velu

    (Emory National Primate Research Center, Emory University
    Emory National Primate Research Center)

  • Tianwei Yu

    (Emory University)

  • Mark Tomai

    (3M Corporate Research and Materials Lab)

  • John Vasilakos

    (3M Drug Delivery Systems)

  • Sudhir P. Kasturi

    (Emory National Primate Research Center)

  • George M. Shaw

    (University of Pennsylvania)

  • David Montefiori

    (Duke University School of Medicine)

  • Steven E. Bosinger

    (Emory National Primate Research Center)

  • Pamela A. Kozlowski

    (Louisiana State University Health Sciences Center)

  • Bali Pulendran

    (Stanford University School of Medicine, Stanford University)

  • Cynthia A. Derdeyn

    (Emory National Primate Research Center
    University of Washington)

  • Eric Hunter

    (Emory National Primate Research Center)

  • Rama R. Amara

    (Emory National Primate Research Center, Emory University
    Emory University)

Abstract

Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2 simian-human immunodeficiency virus (SHIV) challenges in female macaques. Both routes of vaccination induce comparable levels of serum IgG with neutralizing and non-neutralizing activities. The protection in MVA-ID group correlates positively with serum neutralizing and antibody-dependent phagocytic activities, and envelope-specific vaginal IgA; while the limited protection in MVA-IM group correlates only with serum neutralizing activity. MVA-ID immunizations induce greater germinal center Tfh and B cell responses, reduced the ratio of Th1 to Tfh cells in blood and showed lower activation of intermediate monocytes and inflammasome compared to MVA-IM immunizations. This lower innate activation correlates negatively with induction of Tfh responses. These data demonstrate that the MVA-ID vaccinations protect against intravaginal SHIV challenges by modulating the innate and T helper responses.

Suggested Citation

  • Venkata S. Bollimpelli & Pradeep B. J Reddy & Sailaja Gangadhara & Tysheena P. Charles & Samantha L. Burton & Gregory K. Tharp & Tiffany M. Styles & Celia C. Labranche & Justin C. Smith & Amit A. Upad, 2023. "Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40430-7
    DOI: 10.1038/s41467-023-40430-7
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    1. Patricia A. Darrah & Joseph J. Zeppa & Pauline Maiello & Joshua A. Hackney & Marc H. Wadsworth & Travis K. Hughes & Supriya Pokkali & Phillip A. Swanson & Nicole L. Grant & Mark A. Rodgers & Megha Kam, 2020. "Prevention of tuberculosis in macaques after intravenous BCG immunization," Nature, Nature, vol. 577(7788), pages 95-102, January.
    2. Andrew T. Jones & Xiaoying Shen & Korey L. Walter & Celia C. LaBranche & Linda S. Wyatt & Georgia D. Tomaras & David C. Montefiori & Bernard Moss & Dan H. Barouch & John D. Clements & Pamela A. Kozlow, 2019. "HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    3. Michael G. Hudgens & Peter B. Gilbert, 2009. "Assessing Vaccine Effects in Repeated Low-Dose Challenge Experiments," Biometrics, The International Biometric Society, vol. 65(4), pages 1223-1232, December.
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