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The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis

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  • Randy B. Stockbridge

    (University of Michigan)

  • Lawrence P. Wackett

    (University of Minnesota)

Abstract

Fluorinated organic chemicals, such as per- and polyfluorinated alkyl substances (PFAS) and fluorinated pesticides, are both broadly useful and unusually long-lived. To combat problems related to the accumulation of these compounds, microbial PFAS and organofluorine degradation and biosynthesis of less-fluorinated replacement chemicals are under intense study. Both efforts are undermined by the substantial toxicity of fluoride, an anion that powerfully inhibits metabolism. Microorganisms have contended with environmental mineral fluoride over evolutionary time, evolving a suite of detoxification mechanisms. In this perspective, we synthesize emerging ideas on microbial defluorination/fluorination and fluoride resistance mechanisms and identify best approaches for bioengineering new approaches for degrading and making organofluorine compounds.

Suggested Citation

  • Randy B. Stockbridge & Lawrence P. Wackett, 2024. "The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49018-1
    DOI: 10.1038/s41467-024-49018-1
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    References listed on IDEAS

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    1. Changjiang Dong & Fanglu Huang & Hai Deng & Christoph Schaffrath & Jonathan B. Spencer & David O'Hagan & James H. Naismith, 2004. "Crystal structure and mechanism of a bacterial fluorinating enzyme," Nature, Nature, vol. 427(6974), pages 561-565, February.
    2. Randy B. Stockbridge & Akiko Koide & Christopher Miller & Shohei Koide, 2014. "Proof of dual-topology architecture of Fluc F− channels with monobody blockers," Nature Communications, Nature, vol. 5(1), pages 1-5, December.
    3. Aiming Ren & Kanagalaghatta R. Rajashankar & Dinshaw J. Patel, 2012. "Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch," Nature, Nature, vol. 486(7401), pages 85-89, June.
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