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Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue

Author

Listed:
  • Jonas A. Hosp

    (University of Freiburg)

  • Marco Reisert

    (University of Freiburg
    University of Freiburg)

  • Andrea Dressing

    (University of Freiburg
    University of Freiburg)

  • Veronika Götz

    (University of Freiburg)

  • Elias Kellner

    (University of Freiburg)

  • Hansjörg Mast

    (University of Freiburg)

  • Susan Arndt

    (University of Freiburg)

  • Cornelius F. Waller

    (University of Freiburg)

  • Dirk Wagner

    (University of Freiburg)

  • Siegbert Rieg

    (University of Freiburg)

  • Horst Urbach

    (University of Freiburg)

  • Cornelius Weiller

    (University of Freiburg)

  • Nils Schröter

    (University of Freiburg)

  • Alexander Rau

    (University of Freiburg)

Abstract

After contracting COVID-19, a substantial number of individuals develop a Post-COVID-Condition, marked by neurologic symptoms such as cognitive deficits, olfactory dysfunction, and fatigue. Despite this, biomarkers and pathophysiological understandings of this condition remain limited. Employing magnetic resonance imaging, we conduct a comparative analysis of cerebral microstructure among patients with Post-COVID-Condition, healthy controls, and individuals that contracted COVID-19 without long-term symptoms. We reveal widespread alterations in cerebral microstructure, attributed to a shift in volume from neuronal compartments to free fluid, associated with the severity of the initial infection. Correlating these alterations with cognition, olfaction, and fatigue unveils distinct affected networks, which are in close anatomical-functional relationship with the respective symptoms.

Suggested Citation

  • Jonas A. Hosp & Marco Reisert & Andrea Dressing & Veronika Götz & Elias Kellner & Hansjörg Mast & Susan Arndt & Cornelius F. Waller & Dirk Wagner & Siegbert Rieg & Horst Urbach & Cornelius Weiller & N, 2024. "Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48651-0
    DOI: 10.1038/s41467-024-48651-0
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    References listed on IDEAS

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    1. Viet-Thi Tran & Raphaël Porcher & Isabelle Pane & Philippe Ravaud, 2022. "Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
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