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The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova

Author

Listed:
  • Melanie H. Chitwood

    (60 College Street)

  • Caroline Colijn

    (8888 University Drive West)

  • Chongguang Yang

    (Guangzhou University Town Guangdong)

  • Valeriu Crudu

    (Strada Constantin Vârnav 13)

  • Nelly Ciobanu

    (Strada Constantin Vârnav 13)

  • Alexandru Codreanu

    (Strada Constantin Vârnav 13)

  • Jaehee Kim

    (237 Tower Road)

  • Isabel Rancu

    (60 College Street)

  • Kyu Rhee

    (1300 York Ave)

  • Ted Cohen

    (60 College Street)

  • Benjamin Sobkowiak

    (60 College Street)

Abstract

The projected trajectory of multidrug resistant tuberculosis (MDR-TB) epidemics depends on the reproductive fitness of circulating strains of MDR M. tuberculosis (Mtb). Previous efforts to characterize the fitness of MDR Mtb have found that Mtb strains of the Beijing sublineage (Lineage 2.2.1) may be more prone to develop resistance and retain fitness in the presence of resistance-conferring mutations than other lineages. Using Mtb genome sequences from all culture-positive cases collected over two years in Moldova, we estimate the fitness of Ural (Lineage 4.2) and Beijing strains, the two lineages in which MDR is concentrated in the country. We estimate that the fitness of MDR Ural strains substantially exceeds that of other susceptible and MDR strains, and we identify several mutations specific to these MDR Ural strains. Our findings suggest that MDR Ural Mtb has been transmitting efficiently in Moldova and poses a substantial risk of spreading further in the region.

Suggested Citation

  • Melanie H. Chitwood & Caroline Colijn & Chongguang Yang & Valeriu Crudu & Nelly Ciobanu & Alexandru Codreanu & Jaehee Kim & Isabel Rancu & Kyu Rhee & Ted Cohen & Benjamin Sobkowiak, 2024. "The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47282-9
    DOI: 10.1038/s41467-024-47282-9
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    References listed on IDEAS

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    1. Matthias Merker & Jean-Philippe Rasigade & Maxime Barbier & Helen Cox & Silke Feuerriegel & Thomas A. Kohl & Egor Shitikov & Kadri Klaos & Cyril Gaudin & Rudy Antoine & Roland Diel & Sonia Borrell & S, 2022. "Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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