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Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection

Author

Listed:
  • Jian Bing

    (Fudan University
    Shanghai Engineering Research Center of Industrial Microorganisms)

  • Zhangyue Guan

    (Fudan University)

  • Tianhong Zheng

    (Fudan University)

  • Craig L. Ennis

    (University of California, Merced
    University of California, Merced)

  • Clarissa J. Nobile

    (University of California, Merced
    University of California, Merced)

  • Changbin Chen

    (Chinese Academy of Sciences)

  • Haiqing Chu

    (Tongji University
    Tongji University)

  • Guanghua Huang

    (Fudan University
    Southwest University)

Abstract

Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infection. C. auris aggregative cells accumulate in the brain and exhibit obvious advantages over the single-celled yeast-form cells during systemic infection. Genetic mutations, specifically de novo point mutations in genes associated with cell division or budding processes, underlie the rapid evolution of this aggregative phenotype. Most mutated C. auris genes are associated with the regulation of cell wall integrity, cytokinesis, cytoskeletal properties, and cellular polarization. Moreover, the multicellular aggregates are notably more recalcitrant to the host antimicrobial peptides LL-37 and PACAP relative to the single-celled yeast-form cells. Overall, to survive in the host, C. auris can rapidly evolve a multicellular aggregative morphology via genetic mutations.

Suggested Citation

  • Jian Bing & Zhangyue Guan & Tianhong Zheng & Craig L. Ennis & Clarissa J. Nobile & Changbin Chen & Haiqing Chu & Guanghua Huang, 2024. "Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46786-8
    DOI: 10.1038/s41467-024-46786-8
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    References listed on IDEAS

    as
    1. Ying Xie & Jialin Sun & Xiao Han & Alma Turšić-Wunder & Joel D. W. Toh & Wanjin Hong & Yong-Gui Gao & Yansong Miao, 2019. "Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization," Nature Communications, Nature, vol. 10(1), pages 1-18, December.
    2. Yuanyuan Wang & Yun Zou & Xiaoqing Chen & Hao Li & Zhe Yin & Baocai Zhang & Yongbin Xu & Yiquan Zhang & Rulin Zhang & Xinhua Huang & Wenhui Yang & Chaoyue Xu & Tong Jiang & Qinyu Tang & Zili Zhou & Yi, 2022. "Innate immune responses against the fungal pathogen Candida auris," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
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