IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-46786-8.html
   My bibliography  Save this article

Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection

Author

Listed:
  • Jian Bing

    (Fudan University
    Shanghai Engineering Research Center of Industrial Microorganisms)

  • Zhangyue Guan

    (Fudan University)

  • Tianhong Zheng

    (Fudan University)

  • Craig L. Ennis

    (University of California, Merced
    University of California, Merced)

  • Clarissa J. Nobile

    (University of California, Merced
    University of California, Merced)

  • Changbin Chen

    (Chinese Academy of Sciences)

  • Haiqing Chu

    (Tongji University
    Tongji University)

  • Guanghua Huang

    (Fudan University
    Southwest University)

Abstract

Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infection. C. auris aggregative cells accumulate in the brain and exhibit obvious advantages over the single-celled yeast-form cells during systemic infection. Genetic mutations, specifically de novo point mutations in genes associated with cell division or budding processes, underlie the rapid evolution of this aggregative phenotype. Most mutated C. auris genes are associated with the regulation of cell wall integrity, cytokinesis, cytoskeletal properties, and cellular polarization. Moreover, the multicellular aggregates are notably more recalcitrant to the host antimicrobial peptides LL-37 and PACAP relative to the single-celled yeast-form cells. Overall, to survive in the host, C. auris can rapidly evolve a multicellular aggregative morphology via genetic mutations.

Suggested Citation

  • Jian Bing & Zhangyue Guan & Tianhong Zheng & Craig L. Ennis & Clarissa J. Nobile & Changbin Chen & Haiqing Chu & Guanghua Huang, 2024. "Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46786-8
    DOI: 10.1038/s41467-024-46786-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-46786-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-46786-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ying Xie & Jialin Sun & Xiao Han & Alma Turšić-Wunder & Joel D. W. Toh & Wanjin Hong & Yong-Gui Gao & Yansong Miao, 2019. "Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization," Nature Communications, Nature, vol. 10(1), pages 1-18, December.
    2. Yuanyuan Wang & Yun Zou & Xiaoqing Chen & Hao Li & Zhe Yin & Baocai Zhang & Yongbin Xu & Yiquan Zhang & Rulin Zhang & Xinhua Huang & Wenhui Yang & Chaoyue Xu & Tong Jiang & Qinyu Tang & Zili Zhou & Yi, 2022. "Innate immune responses against the fungal pathogen Candida auris," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ye Yuan & Lei Chen & Kexu Song & Miaomiao Cheng & Ling Fang & Lingfei Kong & Lanlan Yu & Ruonan Wang & Zhendong Fu & Minmin Sun & Qian Wang & Chengjun Cui & Haojue Wang & Jiuyang He & Xiaonan Wang & Y, 2024. "Stable peptide-assembled nanozyme mimicking dual antifungal actions," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Qianqian Ma & Wahyu Surya & Danxia He & Hanmeng Yang & Xiao Han & Mui Hoon Nai & Chwee Teck Lim & Jaume Torres & Yansong Miao, 2024. "Spa2 remodels ADP-actin via molecular condensation under glucose starvation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46786-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.