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Innate immune responses against the fungal pathogen Candida auris

Author

Listed:
  • Yuanyuan Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health)

  • Yun Zou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health)

  • Xiaoqing Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Hao Li

    (Shanghai Jiao Tong University School of Medicine)

  • Zhe Yin

    (Beijing Institute of Microbiology and Epidemiology)

  • Baocai Zhang

    (Chinese Academy of Sciences)

  • Yongbin Xu

    (Shanghai University of Traditional Chinese Medicine)

  • Yiquan Zhang

    (Jiangnan University)

  • Rulin Zhang

    (Shanghai Jiao Tong University School of Medicine)

  • Xinhua Huang

    (Chinese Academy of Sciences)

  • Wenhui Yang

    (Beijing Institute of Microbiology and Epidemiology)

  • Chaoyue Xu

    (Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health
    Shanghai University)

  • Tong Jiang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Qinyu Tang

    (Tongji University School of Medicine)

  • Zili Zhou

    (Chinese Academy of Sciences)

  • Ying Ji

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yingqi Liu

    (Gannan Medical University)

  • Lingfei Hu

    (Beijing Institute of Microbiology and Epidemiology)

  • Jia Zhou

    (Shanghai Jiaotong University School of Medicine)

  • Yao Zhou

    (Guangxi Academy of Sciences)

  • Jingjun Zhao

    (Tongji University School of Medicine)

  • Ningning Liu

    (Shanghai Jiaotong University School of Medicine)

  • Guanghua Huang

    (Fudan University)

  • Haishuang Chang

    (Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine)

  • Wenxia Fang

    (Guangxi Academy of Sciences)

  • Changbin Chen

    (Chinese Academy of Sciences
    Nanjing Advanced Academy of Life and Health)

  • Dongsheng Zhou

    (Beijing Institute of Microbiology and Epidemiology)

Abstract

Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.

Suggested Citation

  • Yuanyuan Wang & Yun Zou & Xiaoqing Chen & Hao Li & Zhe Yin & Baocai Zhang & Yongbin Xu & Yiquan Zhang & Rulin Zhang & Xinhua Huang & Wenhui Yang & Chaoyue Xu & Tong Jiang & Qinyu Tang & Zili Zhou & Yi, 2022. "Innate immune responses against the fungal pathogen Candida auris," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31201-x
    DOI: 10.1038/s41467-022-31201-x
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    Cited by:

    1. Ye Yuan & Lei Chen & Kexu Song & Miaomiao Cheng & Ling Fang & Lingfei Kong & Lanlan Yu & Ruonan Wang & Zhendong Fu & Minmin Sun & Qian Wang & Chengjun Cui & Haojue Wang & Jiuyang He & Xiaonan Wang & Y, 2024. "Stable peptide-assembled nanozyme mimicking dual antifungal actions," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Jian Bing & Zhangyue Guan & Tianhong Zheng & Craig L. Ennis & Clarissa J. Nobile & Changbin Chen & Haiqing Chu & Guanghua Huang, 2024. "Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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