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Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique

Author

Listed:
  • Nanna Brokhattingen

    (Hospital Clínic – Universitat de Barcelona)

  • Glória Matambisso

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Clemente da Silva

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Eric Neubauer Vickers

    (San Francisco)

  • Arnau Pujol

    (Hospital Clínic – Universitat de Barcelona)

  • Henriques Mbeve

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Pau Cisteró

    (Hospital Clínic – Universitat de Barcelona)

  • Sónia Maculuve

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Boaventura Cuna

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Cardoso Melembe

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Nelo Ndimande

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Brian Palmer

    (San Francisco)

  • Manuel García-Ulloa

    (Hospital Clínic – Universitat de Barcelona)

  • Humberto Munguambe

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Júlia Montaña-Lopez

    (Hospital Clínic – Universitat de Barcelona)

  • Lidia Nhamussua

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Wilson Simone

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Arlindo Chidimatembue

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Beatriz Galatas

    (Hospital Clínic – Universitat de Barcelona
    Centro de Investigação em Saúde de Manhiça (CISM))

  • Caterina Guinovart

    (Hospital Clínic – Universitat de Barcelona)

  • Eduard Rovira-Vallbona

    (Hospital Clínic – Universitat de Barcelona)

  • Francisco Saúte

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Pedro Aide

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Andrés Aranda-Díaz

    (San Francisco)

  • Bryan Greenhouse

    (San Francisco)

  • Eusébio Macete

    (Centro de Investigação em Saúde de Manhiça (CISM)
    Ministry of Health)

  • Alfredo Mayor

    (Hospital Clínic – Universitat de Barcelona
    Centro de Investigação em Saúde de Manhiça (CISM)
    Spanish Consortium for Research in Epidemiology and Public Health (CIBERESP)
    Universidade Eduardo Mondlane)

Abstract

Routine sampling of pregnant women at first antenatal care (ANC) visits could make Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub-Saharan Africa. We compare the genetic structure of parasite populations sampled from 289 first ANC users and 93 children from the community in Mozambique between 2015 and 2019. Samples are amplicon sequenced targeting 165 microhaplotypes and 15 drug resistance genes. Metrics of genetic diversity and relatedness, as well as the prevalence of drug resistance markers, are consistent between the two populations. In an area targeted for elimination, intra-host genetic diversity declines in both populations (p = 0.002-0.007), while for the ANC population, population genetic diversity is also lower (p = 0.0004), and genetic relatedness between infections is higher (p = 0.002) than control areas, indicating a recent reduction in the parasite population size. These results highlight the added value of genomic surveillance at ANC clinics to inform about changes in transmission beyond epidemiological data.

Suggested Citation

  • Nanna Brokhattingen & Glória Matambisso & Clemente da Silva & Eric Neubauer Vickers & Arnau Pujol & Henriques Mbeve & Pau Cisteró & Sónia Maculuve & Boaventura Cuna & Cardoso Melembe & Nelo Ndimande &, 2024. "Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46535-x
    DOI: 10.1038/s41467-024-46535-x
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    References listed on IDEAS

    as
    1. Cody S. Nelson & Kelsey M. Sumner & Elizabeth Freedman & Joseph W. Saelens & Andrew A. Obala & Judith N. Mangeni & Steve M. Taylor & Wendy P. O’Meara, 2019. "High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    2. Magnus Manske & Olivo Miotto & Susana Campino & Sarah Auburn & Jacob Almagro-Garcia & Gareth Maslen & Jack O’Brien & Abdoulaye Djimde & Ogobara Doumbo & Issaka Zongo & Jean-Bosco Ouedraogo & Pascal Mi, 2012. "Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing," Nature, Nature, vol. 487(7407), pages 375-379, July.
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