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High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya

Author

Listed:
  • Cody S. Nelson

    (Duke University)

  • Kelsey M. Sumner

    (University of North Carolina
    Duke University School of Medicine)

  • Elizabeth Freedman

    (Duke University School of Medicine)

  • Joseph W. Saelens

    (Duke University School of Medicine)

  • Andrew A. Obala

    (Moi University College of Health Sciences)

  • Judith N. Mangeni

    (Moi University College of Health Sciences)

  • Steve M. Taylor

    (Duke University
    University of North Carolina
    Duke University School of Medicine)

  • Wendy P. O’Meara

    (Duke University
    Duke University School of Medicine)

Abstract

Novel interventions that leverage the heterogeneity of parasite transmission are needed to achieve malaria elimination. To better understand spatial and temporal dynamics of transmission, we applied amplicon next-generation sequencing of two polymorphic gene regions (csp and ama1) to a cohort identified via reactive case detection in a high-transmission setting in western Kenya. From April 2013 to July 2014, we enrolled 442 symptomatic children with malaria, 442 matched controls, and all household members of both groups. Here, we evaluate genetic similarity between infected individuals using three indices: sharing of parasite haplotypes on binary and proportional scales and the L1 norm. Symptomatic children more commonly share haplotypes with their own household members. Furthermore, we observe robust temporal structuring of parasite genetic similarity and identify the unique molecular signature of an outbreak. These findings of both micro- and macro-scale organization of parasite populations might be harnessed to inform next-generation malaria control measures.

Suggested Citation

  • Cody S. Nelson & Kelsey M. Sumner & Elizabeth Freedman & Joseph W. Saelens & Andrew A. Obala & Judith N. Mangeni & Steve M. Taylor & Wendy P. O’Meara, 2019. "High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13578-4
    DOI: 10.1038/s41467-019-13578-4
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    Cited by:

    1. Nanna Brokhattingen & Glória Matambisso & Clemente da Silva & Eric Neubauer Vickers & Arnau Pujol & Henriques Mbeve & Pau Cisteró & Sónia Maculuve & Boaventura Cuna & Cardoso Melembe & Nelo Ndimande &, 2024. "Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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