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Cell-lysis sensing drives biofilm formation in Vibrio cholerae

Author

Listed:
  • Jojo A. Prentice

    (Carnegie Mellon University)

  • Robert Weerd

    (Carnegie Mellon University)

  • Andrew A. Bridges

    (Carnegie Mellon University)

Abstract

Matrix-encapsulated communities of bacteria, called biofilms, are ubiquitous in the environment and are notoriously difficult to eliminate in clinical and industrial settings. Biofilm formation likely evolved as a mechanism to protect resident cells from environmental challenges, yet how bacteria undergo threat assessment to inform biofilm development remains unclear. Here we find that population-level cell lysis events induce the formation of biofilms by surviving Vibrio cholerae cells. Survivors detect threats by sensing a cellular component released through cell lysis, which we identify as norspermidine. Lysis sensing occurs via the MbaA receptor with genus-level specificity, and responsive biofilm cells are shielded from phage infection and attacks from other bacteria. Thus, our work uncovers a connection between bacterial lysis and biofilm formation that may be broadly conserved among microorganisms.

Suggested Citation

  • Jojo A. Prentice & Robert Weerd & Andrew A. Bridges, 2024. "Cell-lysis sensing drives biofilm formation in Vibrio cholerae," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46399-1
    DOI: 10.1038/s41467-024-46399-1
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    1. Birger Rasmussen, 2000. "Filamentous microfossils in a 3,235-million-year-old volcanogenic massive sulphide deposit," Nature, Nature, vol. 405(6787), pages 676-679, June.
    2. Qiyun Zhu & Uyen Mai & Wayne Pfeiffer & Stefan Janssen & Francesco Asnicar & Jon G. Sanders & Pedro Belda-Ferre & Gabriel A. Al-Ghalith & Evguenia Kopylova & Daniel McDonald & Tomasz Kosciolek & John , 2019. "Phylogenomics of 10,575 genomes reveals evolutionary proximity between domains Bacteria and Archaea," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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