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Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease

Author

Listed:
  • Shixian Hu

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen
    the First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University)

  • Arno R. Bourgonje

    (University of Groningen, University Medical Center Groningen)

  • Ranko Gacesa

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Bernadien H. Jansen

    (University of Groningen, University Medical Center Groningen)

  • Johannes R. Björk

    (University of Groningen, University Medical Center Groningen)

  • Amber Bangma

    (University of Groningen, University Medical Center Groningen)

  • Iwan J. Hidding

    (University of Groningen, University Medical Center Groningen)

  • Hendrik M. van Dullemen

    (University of Groningen, University Medical Center Groningen)

  • Marijn C. Visschedijk

    (University of Groningen, University Medical Center Groningen)

  • Klaas Nico Faber

    (University of Groningen, University Medical Center Groningen)

  • Gerard Dijkstra

    (University of Groningen, University Medical Center Groningen)

  • Hermie J. M. Harmsen

    (University of Groningen, University Medical Center Groningen)

  • Eleonora A. M. Festen

    (University of Groningen, University Medical Center Groningen)

  • Arnau Vich Vila

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Lieke M. Spekhorst

    (University of Groningen, University Medical Center Groningen
    Medisch Spectrum Twente)

  • Rinse K. Weersma

    (University of Groningen, University Medical Center Groningen)

Abstract

Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specific interactions, we perform transcriptomic (RNA-seq) and microbial (16S-rRNA-seq) profiling of 697 intestinal biopsies (645 derived from 335 patients with IBD and 52 from 16 non-IBD controls). Mucosal gene expression patterns in IBD are mainly determined by tissue location and inflammation, whereas the mucosal microbiota composition shows a high degree of individual specificity. Analysis of transcript-bacteria interactions identifies six distinct groups of inflammation-related pathways that are associated with intestinal microbiota (adjusted P

Suggested Citation

  • Shixian Hu & Arno R. Bourgonje & Ranko Gacesa & Bernadien H. Jansen & Johannes R. Björk & Amber Bangma & Iwan J. Hidding & Hendrik M. van Dullemen & Marijn C. Visschedijk & Klaas Nico Faber & Gerard D, 2024. "Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45855-2
    DOI: 10.1038/s41467-024-45855-2
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    References listed on IDEAS

    as
    1. Shixian Hu & Werna T. Uniken Venema & Harm-Jan Westra & Arnau Vich Vila & Ruggero Barbieri & Michiel D. Voskuil & Tjasso Blokzijl & Bernadien H. Jansen & Yanni Li & Mark J. Daly & Ramnik J. Xavier & G, 2021. "Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
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