IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-21458-z.html
   My bibliography  Save this article

Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

Author

Listed:
  • Shixian Hu

    (University of Groningen and University Medical Center Groningen
    University of Groningen and University Medical Center Groningen)

  • Werna T. Uniken Venema

    (University of Groningen and University Medical Center Groningen
    University of Groningen and University Medical Center Groningen)

  • Harm-Jan Westra

    (University of Groningen and University Medical Center Groningen)

  • Arnau Vich Vila

    (University of Groningen and University Medical Center Groningen
    University of Groningen and University Medical Center Groningen)

  • Ruggero Barbieri

    (University of Groningen and University Medical Center Groningen
    University of Groningen and University Medical Center Groningen)

  • Michiel D. Voskuil

    (University of Groningen and University Medical Center Groningen)

  • Tjasso Blokzijl

    (University of Groningen and University Medical Center Groningen)

  • Bernadien H. Jansen

    (University of Groningen and University Medical Center Groningen)

  • Yanni Li

    (University of Groningen and University Medical Center Groningen
    University of Groningen and University Medical Center Groningen)

  • Mark J. Daly

    (Broad Institute of Harvard and Massachusetts Institute of Technology
    University of Helsinki)

  • Ramnik J. Xavier

    (Broad Institute of Harvard and Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Gerard Dijkstra

    (University of Groningen and University Medical Center Groningen)

  • Eleonora A. Festen

    (University of Groningen and University Medical Center Groningen
    University of Groningen and University Medical Center Groningen)

  • Rinse K. Weersma

    (University of Groningen and University Medical Center Groningen)

Abstract

More than 240 genetic risk loci have been associated with inflammatory bowel disease (IBD), but little is known about how they contribute to disease development in involved tissue. Here, we hypothesized that host genetic variation affects gene expression in an inflammation-dependent way, and investigated 299 snap-frozen intestinal biopsies from inflamed and non-inflamed mucosa from 171 IBD patients. RNA-sequencing was performed, and genotypes were determined using whole exome sequencing and genome wide genotyping. In total, 28,746 genes and 6,894,979 SNPs were included. Linear mixed models identified 8,881 independent intestinal cis-expression quantitative trait loci (cis-eQTLs) (FDR

Suggested Citation

  • Shixian Hu & Werna T. Uniken Venema & Harm-Jan Westra & Arnau Vich Vila & Ruggero Barbieri & Michiel D. Voskuil & Tjasso Blokzijl & Bernadien H. Jansen & Yanni Li & Mark J. Daly & Ramnik J. Xavier & G, 2021. "Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21458-z
    DOI: 10.1038/s41467-021-21458-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-21458-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-21458-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shixian Hu & Arno R. Bourgonje & Ranko Gacesa & Bernadien H. Jansen & Johannes R. Björk & Amber Bangma & Iwan J. Hidding & Hendrik M. van Dullemen & Marijn C. Visschedijk & Klaas Nico Faber & Gerard D, 2024. "Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21458-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.