IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45325-9.html
   My bibliography  Save this article

A multicenter clinical AI system study for detection and diagnosis of focal liver lesions

Author

Listed:
  • Hanning Ying

    (Zhejiang University School of Medicine)

  • Xiaoqing Liu

    (Deepwise Artificial Intelligence Laboratory)

  • Min Zhang

    (Zhejiang University)

  • Yiyue Ren

    (Zhejiang University)

  • Shihui Zhen

    (Zhejiang University)

  • Xiaojie Wang

    (Zhejiang University)

  • Bo Liu

    (Deepwise Artificial Intelligence Laboratory)

  • Peng Hu

    (Zhejiang University School of Medicine)

  • Lian Duan

    (Zhejiang University School of Medicine)

  • Mingzhi Cai

    (Zhangzhou Municipal Hospital of Fujian Province)

  • Ming Jiang

    (Quzhou People’s Hospital)

  • Xiangdong Cheng

    (Cancer Hospital of the University of Chinese Academy of Sciences (ZheJiang Cancer Hospital))

  • Xiangyang Gong

    (Zhejiang Provincial People’s Hospital)

  • Haitao Jiang

    (Cancer Hospital of the University of Chinese Academy of Sciences (ZheJiang Cancer Hospital))

  • Jianshuai Jiang

    (Ningbo First Hospital)

  • Jianjun Zheng

    (University of Chinese Academy of Sciences (Ningbo No.2 Hospital))

  • Kelei Zhu

    (Yinzhou People’s Hospital)

  • Wei Zhou

    (Affiliated Central Hospital of Huzhou University)

  • Baochun Lu

    (Shaoxing People’s Hospital)

  • Hongkun Zhou

    (The First Hospital of Jiaxing Affiliated Hospital of Jiaxing University)

  • Yiyu Shen

    (The Second Hospital of Jiaxing Affiliated Hospital of Jiaxing University)

  • Jinlin Du

    (Jinhua Municipal Central Hospital)

  • Mingliang Ying

    (Jinhua Municipal Central Hospital)

  • Qiang Hong

    (Jinhua GuangFU Hospital)

  • Jingang Mo

    (Taizhou Municipal Central Hospital)

  • Jianfeng Li

    (The First People’s Hospital of Wenling)

  • Guanxiong Ye

    (Lishui People’s Hospital)

  • Shizheng Zhang

    (Zhejiang University School of Medicine)

  • Hongjie Hu

    (Zhejiang University School of Medicine)

  • Jihong Sun

    (Zhejiang University School of Medicine)

  • Hui Liu

    (Zhejiang University School of Medicine)

  • Yiming Li

    (Deepwise Artificial Intelligence Laboratory)

  • Xingxin Xu

    (Deepwise Artificial Intelligence Laboratory)

  • Huiping Bai

    (Deepwise Artificial Intelligence Laboratory)

  • Shuxin Wang

    (Deepwise Artificial Intelligence Laboratory)

  • Xin Cheng

    (Xiamen University)

  • Xiaoyin Xu

    (Harvard Medical School)

  • Long Jiao

    (Imperial College London)

  • Risheng Yu

    (Second Affiliated Hospital of Zhejiang University School of Medicine)

  • Wan Yee Lau

    (the Chinese University of Hong Kong)

  • Yizhou Yu

    (Department of Computer Science, The University of Hong Kong)

  • Xiujun Cai

    (Zhejiang University School of Medicine)

Abstract

Early and accurate diagnosis of focal liver lesions is crucial for effective treatment and prognosis. We developed and validated a fully automated diagnostic system named Liver Artificial Intelligence Diagnosis System (LiAIDS) based on a diverse sample of 12,610 patients from 18 hospitals, both retrospectively and prospectively. In this study, LiAIDS achieved an F1-score of 0.940 for benign and 0.692 for malignant lesions, outperforming junior radiologists (benign: 0.830-0.890, malignant: 0.230-0.360) and being on par with senior radiologists (benign: 0.920-0.950, malignant: 0.550-0.650). Furthermore, with the assistance of LiAIDS, the diagnostic accuracy of all radiologists improved. For benign and malignant lesions, junior radiologists’ F1-scores improved to 0.936-0.946 and 0.667-0.680 respectively, while seniors improved to 0.950-0.961 and 0.679-0.753. Additionally, in a triage study of 13,192 consecutive patients, LiAIDS automatically classified 76.46% of patients as low risk with a high NPV of 99.0%. The evidence suggests that LiAIDS can serve as a routine diagnostic tool and enhance the diagnostic capabilities of radiologists for liver lesions.

Suggested Citation

  • Hanning Ying & Xiaoqing Liu & Min Zhang & Yiyue Ren & Shihui Zhen & Xiaojie Wang & Bo Liu & Peng Hu & Lian Duan & Mingzhi Cai & Ming Jiang & Xiangdong Cheng & Xiangyang Gong & Haitao Jiang & Jianshuai, 2024. "A multicenter clinical AI system study for detection and diagnosis of focal liver lesions," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45325-9
    DOI: 10.1038/s41467-024-45325-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45325-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45325-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Andre Esteva & Brett Kuprel & Roberto A. Novoa & Justin Ko & Susan M. Swetter & Helen M. Blau & Sebastian Thrun, 2017. "Correction: Corrigendum: Dermatologist-level classification of skin cancer with deep neural networks," Nature, Nature, vol. 546(7660), pages 686-686, June.
    2. Andre Esteva & Brett Kuprel & Roberto A. Novoa & Justin Ko & Susan M. Swetter & Helen M. Blau & Sebastian Thrun, 2017. "Dermatologist-level classification of skin cancer with deep neural networks," Nature, Nature, vol. 542(7639), pages 115-118, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lin Lu & Laurent Dercle & Binsheng Zhao & Lawrence H. Schwartz, 2021. "Deep learning for the prediction of early on-treatment response in metastatic colorectal cancer from serial medical imaging," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Zheng Yan & Wenqian Robertson & Yaosheng Lou & Tom W. Robertson & Sung Yong Park, 2021. "Finding leading scholars in mobile phone behavior: a mixed-method analysis of an emerging interdisciplinary field," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(12), pages 9499-9517, December.
    3. Freddy Gabbay & Rotem Lev Aharoni & Ori Schweitzer, 2022. "Deep Neural Network Memory Performance and Throughput Modeling and Simulation Framework," Mathematics, MDPI, vol. 10(21), pages 1-20, November.
    4. Jungyoon Kim & Jihye Lim, 2021. "A Deep Neural Network-Based Method for Prediction of Dementia Using Big Data," IJERPH, MDPI, vol. 18(10), pages 1-13, May.
    5. Gang Yu & Kai Sun & Chao Xu & Xing-Hua Shi & Chong Wu & Ting Xie & Run-Qi Meng & Xiang-He Meng & Kuan-Song Wang & Hong-Mei Xiao & Hong-Wen Deng, 2021. "Accurate recognition of colorectal cancer with semi-supervised deep learning on pathological images," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    6. DonHee Lee & Seong No Yoon, 2021. "Application of Artificial Intelligence-Based Technologies in the Healthcare Industry: Opportunities and Challenges," IJERPH, MDPI, vol. 18(1), pages 1-18, January.
    7. Claus Zippel & Sabine Bohnet-Joschko, 2021. "Rise of Clinical Studies in the Field of Machine Learning: A Review of Data Registered in ClinicalTrials.gov," IJERPH, MDPI, vol. 18(10), pages 1-14, May.
    8. Dario Sipari & Betsy D. M. Chaparro-Rico & Daniele Cafolla, 2022. "SANE (Easy Gait Analysis System): Towards an AI-Assisted Automatic Gait-Analysis," IJERPH, MDPI, vol. 19(16), pages 1-27, August.
    9. Jamil Ahmad & Abdul Khader Jilani Saudagar & Khalid Mahmood Malik & Waseem Ahmad & Muhammad Badruddin Khan & Mozaherul Hoque Abul Hasanat & Abdullah AlTameem & Mohammed AlKhathami & Muhammad Sajjad, 2022. "Disease Progression Detection via Deep Sequence Learning of Successive Radiographic Scans," IJERPH, MDPI, vol. 19(1), pages 1-16, January.
    10. Rasheed Omobolaji Alabi & Alhadi Almangush & Mohammed Elmusrati & Ilmo Leivo & Antti Mäkitie, 2022. "Measuring the Usability and Quality of Explanations of a Machine Learning Web-Based Tool for Oral Tongue Cancer Prognostication," IJERPH, MDPI, vol. 19(14), pages 1-13, July.
    11. Andreas Fügener & Jörn Grahl & Alok Gupta & Wolfgang Ketter, 2022. "Cognitive Challenges in Human–Artificial Intelligence Collaboration: Investigating the Path Toward Productive Delegation," Information Systems Research, INFORMS, vol. 33(2), pages 678-696, June.
    12. Vidhya V. & Anjan Gudigar & U. Raghavendra & Ajay Hegde & Girish R. Menon & Filippo Molinari & Edward J. Ciaccio & U. Rajendra Acharya, 2021. "Automated Detection and Screening of Traumatic Brain Injury (TBI) Using Computed Tomography Images: A Comprehensive Review and Future Perspectives," IJERPH, MDPI, vol. 18(12), pages 1-29, June.
    13. Pujin Wang & Jianzhuang Xiao & Ken’ichi Kawaguchi & Lichen Wang, 2022. "Automatic Ceiling Damage Detection in Large-Span Structures Based on Computer Vision and Deep Learning," Sustainability, MDPI, vol. 14(6), pages 1-24, March.
    14. Xu Gong & Keqin Guan & Qiyang Chen, 2022. "The role of textual analysis in oil futures price forecasting based on machine learning approach," Journal of Futures Markets, John Wiley & Sons, Ltd., vol. 42(10), pages 1987-2017, October.
    15. Julian Schiele & Thomas Koperna & Jens O. Brunner, 2021. "Predicting intensive care unit bed occupancy for integrated operating room scheduling via neural networks," Naval Research Logistics (NRL), John Wiley & Sons, vol. 68(1), pages 65-88, February.
    16. Kai Feng & Han Hong & Ke Tang & Jingyuan Wang, 2023. "Statistical Tests for Replacing Human Decision Makers with Algorithms," Papers 2306.11689, arXiv.org.
    17. He, Wenbin & Liu, Ting & Ming, Wuyi & Li, Zongze & Du, Jinguang & Li, Xiaoke & Guo, Xudong & Sun, Peiyan, 2024. "Progress in prediction of remaining useful life of hydrogen fuel cells based on deep learning," Renewable and Sustainable Energy Reviews, Elsevier, vol. 192(C).
    18. Oded Rotem & Tamar Schwartz & Ron Maor & Yishay Tauber & Maya Tsarfati Shapiro & Marcos Meseguer & Daniella Gilboa & Daniel S. Seidman & Assaf Zaritsky, 2024. "Visual interpretability of image-based classification models by generative latent space disentanglement applied to in vitro fertilization," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    19. Zhiming Cui & Yu Fang & Lanzhuju Mei & Bojun Zhang & Bo Yu & Jiameng Liu & Caiwen Jiang & Yuhang Sun & Lei Ma & Jiawei Huang & Yang Liu & Yue Zhao & Chunfeng Lian & Zhongxiang Ding & Min Zhu & Dinggan, 2022. "A fully automatic AI system for tooth and alveolar bone segmentation from cone-beam CT images," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    20. Chowdhury, Emon Kalyan, 2019. "Use of Artificial Intelligence in Stock Trading," MPRA Paper 118175, University Library of Munich, Germany, revised 18 Apr 2019.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45325-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.