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Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

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  • Darja Andreev

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Katerina Kachler

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Mengdan Liu

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    Zhejiang University – School of Medicine)

  • Zhu Chen

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    Anhui Medical University Affiliated Provincial Hospital)

  • Brenda Krishnacoumar

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    University Hospital Essen, University of Duisburg-Essen)

  • Mark Ringer

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Silke Frey

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Gerhard Krönke

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI)
    Charité University Medicine)

  • David Voehringer

    (FAU Erlangen-Nürnberg and Universitätsklinikum Erlangen)

  • Georg Schett

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

  • Aline Bozec

    (Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
    Deutsches Zentrum für Immuntherapie (DZI))

Abstract

Eosinophils are involved in tissue homeostasis. Herein, we unveiled eosinophils as important regulators of bone homeostasis. Eosinophils are localized in proximity to bone-resorbing osteoclasts in the bone marrow. The absence of eosinophils in ΔdblGATA mice results in lower bone mass under steady-state conditions and amplified bone loss upon sex hormone deprivation and inflammatory arthritis. Conversely, increased numbers of eosinophils in IL-5 transgenic mice enhance bone mass under steady-state conditions and protect from hormone- and inflammation- mediated bone loss. Eosinophils strongly inhibit the differentiation and demineralization activity of osteoclasts and lead to profound changes in the transcriptional profile of osteoclasts. This osteoclast-suppressive effect of eosinophils is based on the release of eosinophil peroxidase causing impaired reactive oxygen species and mitogen-activated protein kinase induction in osteoclast precursors. In humans, the number and the activity of eosinophils correlates with bone mass in healthy participants and rheumatoid arthritis patients. Taken together, experimental and human data indicate a regulatory function of eosinophils on bone.

Suggested Citation

  • Darja Andreev & Katerina Kachler & Mengdan Liu & Zhu Chen & Brenda Krishnacoumar & Mark Ringer & Silke Frey & Gerhard Krönke & David Voehringer & Georg Schett & Aline Bozec, 2024. "Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45261-8
    DOI: 10.1038/s41467-024-45261-8
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    References listed on IDEAS

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    1. Stephan Culemann & Anika Grüneboom & José Ángel Nicolás-Ávila & Daniela Weidner & Katrin Franziska Lämmle & Tobias Rothe & Juan A. Quintana & Philipp Kirchner & Branislav Krljanac & Martin Eberhardt &, 2019. "Locally renewing resident synovial macrophages provide a protective barrier for the joint," Nature, Nature, vol. 572(7771), pages 670-675, August.
    2. Christian E. Jacome-Galarza & Gulce I. Percin & James T. Muller & Elvira Mass & Tomi Lazarov & Jiri Eitler & Martina Rauner & Vijay K. Yadav & Lucile Crozet & Mathieu Bohm & Pierre-Louis Loyher & Gera, 2019. "Developmental origin, functional maintenance and genetic rescue of osteoclasts," Nature, Nature, vol. 568(7753), pages 541-545, April.
    3. Zhu Chen & Darja Andreev & Katharina Oeser & Branislav Krljanac & Axel Hueber & Arnd Kleyer & David Voehringer & Georg Schett & Aline Bozec, 2016. "Th2 and eosinophil responses suppress inflammatory arthritis," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
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