IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45076-7.html
   My bibliography  Save this article

Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions

Author

Listed:
  • Qiyuan Chen

    (University of Wisconsin-Madison)

  • Hang Zhai

    (University of Wisconsin-Madison)

  • David J. Beebe

    (University of Wisconsin-Madison
    Department of Pathology and Laboratory Medicine
    University of Wisconsin-Madison)

  • Chao Li

    (University of Wisconsin-Madison)

  • Bu Wang

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

Abstract

Under-oil open microfluidic system, utilizing liquid-liquid boundaries for confinements, offers inherent advantages including clogging-free flow channels, flexible access to samples, and adjustable gas permeation, making it well-suited for studying multi-phase chemical reactions that are challenging for closed microfluidics. However, reports on the novel system have primarily focused on device fabrication and functionality demonstrations within biology, leaving their application in broader chemical analysis underexplored. Here, we present a visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions with Raman spectroscopy. The enhanced system utilizes a semi-transparent silicon (Si) nanolayer over the substrate to enhance visualization in both inverted and upright microscope setups while reducing Raman noise from the substrate. We validated the system’s chemical stability and capability to monitor gas evolution and gas-liquid reactions in situ. The enhanced under-oil open microfluidic system, integrating Raman spectroscopy, offers a robust open-microfluidic platform for label-free molecular sensing and real-time chemical/biochemical process monitoring in multi-phase systems.

Suggested Citation

  • Qiyuan Chen & Hang Zhai & David J. Beebe & Chao Li & Bu Wang, 2024. "Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45076-7
    DOI: 10.1038/s41467-024-45076-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45076-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45076-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Wenqian Feng & Yu Chai & Joe Forth & Paul D. Ashby & Thomas P. Russell & Brett A. Helms, 2019. "Harnessing liquid-in-liquid printing and micropatterned substrates to fabricate 3-dimensional all-liquid fluidic devices," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sai Zhao & Yongkang Jiang & Yuchen Fu & Wei Chen & Qinrong Zhang & Liulin He & Changxiong Huang & Yao Liu & Xiao Cheng Zeng & Yu Chai, 2024. "Chaperone solvent-assisted assembly of polymers at the interface of two immiscible liquids," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Chongrui Zhang & Xufei Liu & Jiang Gong & Qiang Zhao, 2023. "Liquid sculpture and curing of bio-inspired polyelectrolyte aqueous two-phase systems," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Youngsun Kim & Hongru Ding & Yuebing Zheng, 2022. "Investigating water/oil interfaces with opto-thermophoresis," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    4. Parisa Bazazi & Howard A. Stone & S. Hossein Hejazi, 2022. "Spongy all-in-liquid materials by in-situ formation of emulsions at oil-water interfaces," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45076-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.