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Early onset diagnosis in Alzheimer’s disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid

Author

Listed:
  • Jusung An

    (Korea University)

  • Kyeonghwan Kim

    (Yonsei University
    Yonsei University)

  • Ho Jae Lim

    (Chosun University)

  • Hye Yun Kim

    (Yonsei University
    Yonsei University)

  • Jinwoo Shin

    (Korea University)

  • InWook Park

    (Yonsei University
    Yonsei University)

  • Illhwan Cho

    (Yonsei University
    Yonsei University)

  • Hyeong Yun Kim

    (Yonsei University)

  • Sunghoon Kim

    (Yonsei University
    Yonsei University
    Yonsei University)

  • Catriona McLean

    (The Alfred Hospital)

  • Kyu Yeong Choi

    (Chosun University)

  • YoungSoo Kim

    (Yonsei University
    Yonsei University)

  • Kun Ho Lee

    (Chosun University
    Chosun University
    Korea Brain Research Institute)

  • Jong Seung Kim

    (Korea University
    TheranoChem Incorporation, Seongbuk-gu)

Abstract

Amyloid-β (Aβ) oligomers are implicated in the onset of Alzheimer’s disease (AD). Herein, quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for detecting Aβ oligomers by finely tailoring the hydrophobicity of the biannulate donor motifs in donor-π-acceptor structure. Q-OB shows a great sensing potency in dynamically monitoring oligomerization of Aβ during amyloid fibrillogenesis in vitro. In addition, we applied this strategy to fluorometrically analyze Aβ self-assembly kinetics in the cerebrospinal fluids (CSF) of AD patients. The fluorescence intensity of Q-OB in AD patients’ CSF revealed a marked change of log (I/I0) value of 0.34 ± 0.13 (cognitive normal), 0.15 ± 0.12 (mild cognitive impairment), and 0.14 ± 0.10 (AD dementia), guiding to distinguish a state of AD continuum for early diagnosis of AD. These studies demonstrate the potential of our approach can expand the currently available preclinical diagnostic platform for the early stages of AD, aiding in the disruption of pathological progression and the development of appropriate treatment strategies.

Suggested Citation

  • Jusung An & Kyeonghwan Kim & Ho Jae Lim & Hye Yun Kim & Jinwoo Shin & InWook Park & Illhwan Cho & Hyeong Yun Kim & Sunghoon Kim & Catriona McLean & Kyu Yeong Choi & YoungSoo Kim & Kun Ho Lee & Jong Se, 2024. "Early onset diagnosis in Alzheimer’s disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44818-x
    DOI: 10.1038/s41467-024-44818-x
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    References listed on IDEAS

    as
    1. Jeff Sevigny & Ping Chiao & Thierry Bussière & Paul H. Weinreb & Leslie Williams & Marcel Maier & Robert Dunstan & Stephen Salloway & Tianle Chen & Yan Ling & John O’Gorman & Fang Qian & Mahin Arastu , 2016. "The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease," Nature, Nature, vol. 537(7618), pages 50-56, September.
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