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Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes

Author

Listed:
  • Yuxi Gao

    (Yunnan University)

  • Lijuan Gao

    (Yunnan University)

  • Endiao Zhu

    (Yunnan University)

  • Yunhong Yang

    (Yunnan University)

  • Mi Jie

    (Yunnan University)

  • Jiaqian Zhang

    (Yunnan University)

  • Zhiqiang Pan

    (Yunnan University)

  • Chengfeng Xia

    (Yunnan University)

Abstract

Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp3)−C(sp3) bond and one C(sp3)−C(sp2) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds.

Suggested Citation

  • Yuxi Gao & Lijuan Gao & Endiao Zhu & Yunhong Yang & Mi Jie & Jiaqian Zhang & Zhiqiang Pan & Chengfeng Xia, 2023. "Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43748-4
    DOI: 10.1038/s41467-023-43748-4
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    References listed on IDEAS

    as
    1. John J. Murphy & Paolo Melchiorre, 2015. "Light opens pathways for nickel catalysis," Nature, Nature, vol. 524(7565), pages 297-298, August.
    2. Sarah Z. Tasker & Eric A. Standley & Timothy F. Jamison, 2014. "Erratum: Recent advances in homogeneous nickel catalysis," Nature, Nature, vol. 510(7503), pages 176-176, June.
    3. Sarah Z. Tasker & Eric A. Standley & Timothy F. Jamison, 2014. "Recent advances in homogeneous nickel catalysis," Nature, Nature, vol. 509(7500), pages 299-309, May.
    4. Radek Cibulka, 2020. "Strong chemical reducing agents produced by light," Nature, Nature, vol. 580(7801), pages 31-32, April.
    5. Pengcheng Qian & Haixing Guan & Yan-En Wang & Qianqian Lu & Fan Zhang & Dan Xiong & Patrick J. Walsh & Jianyou Mao, 2021. "Catalytic enantioselective reductive domino alkyl arylation of acrylates via nickel/photoredox catalysis," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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