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A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus

Author

Listed:
  • Peng Liu

    (Ningbo University)

  • Chaonan Shi

    (Henan Agricultural University)

  • Shuang Liu

    (Ningbo University)

  • Jiajia Lei

    (Ningbo University)

  • Qisen Lu

    (Ningbo University)

  • Haichao Hu

    (Ningbo University)

  • Yan Ren

    (Henan Agricultural University)

  • Ning Zhang

    (Henan Agricultural University)

  • Congwei Sun

    (Henan Agricultural University)

  • Lu Chen

    (Ningbo University)

  • Yaoyao Jiang

    (Ningbo University)

  • Lixiao Feng

    (Ningbo University)

  • Tianye Zhang

    (Ningbo University)

  • Kaili Zhong

    (Ningbo University)

  • Jiaqian Liu

    (Ningbo University)

  • Juan Zhang

    (Ningbo University)

  • Zhuo Zhang

    (Hunan Academy of Agricultural Sciences)

  • Bingjian Sun

    (Henan Agricultural University)

  • Jianping Chen

    (Ningbo University)

  • Yimiao Tang

    (Beijing Academy of Agriculture and Forestry Sciences)

  • Feng Chen

    (Henan Agricultural University)

  • Jian Yang

    (Ningbo University)

Abstract

Wheat yellow mosaic virus (WYMV), a soil-borne pathogen, poses a serious threat to global wheat production. Here, we identify a WYMV resistance gene, TaRD21A, that belongs to the papain-like cysteine protease family. Through genetic manipulation of TaRD21A expression, we establish its positive role in the regulation of wheat to WYMV resistance. Furthermore, our investigation shows that the TaRD21A-mediated plant antiviral response relies on the release of a small peptide catalyzed by TaRD21A protease activity. To counteract wheat resistance, WYMV-encoded nuclear inclusion protease-a (NIa) suppress TaRD21A activity to promote virus infection. In resistant cultivars, a natural variant of TaRD21A features a alanine to serine substitution and this substitution enables the phosphorylation of Serine, thereby weakening the interaction between NIa and TaRD21A, reinforcing wheat resistance against WYMV. Our study not only unveils a WYMV resistance gene but also offers insights into the intricate mechanisms underpinning resistance against WYMV.

Suggested Citation

  • Peng Liu & Chaonan Shi & Shuang Liu & Jiajia Lei & Qisen Lu & Haichao Hu & Yan Ren & Ning Zhang & Congwei Sun & Lu Chen & Yaoyao Jiang & Lixiao Feng & Tianye Zhang & Kaili Zhong & Jiaqian Liu & Juan Z, 2023. "A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43643-y
    DOI: 10.1038/s41467-023-43643-y
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    References listed on IDEAS

    as
    1. Zongyu Gao & Dingliang Zhang & Xiaoling Wang & Xin Zhang & Zhiyan Wen & Qianshen Zhang & Dawei Li & Savithramma P. Dinesh-Kumar & Yongliang Zhang, 2022. "Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Ying-Lan Chen & Fan-Wei Lin & Kai-Tan Cheng & Chi-Hsin Chang & Sheng-Chi Hung & Thomas Efferth & Yet-Ran Chen, 2023. "XCP1 cleaves Pathogenesis-related protein 1 into CAPE9 for systemic immunity in Arabidopsis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
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