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The rate of epigenetic drift scales with maximum lifespan across mammals

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  • Emily M. Bertucci-Richter

    (University of Georgia
    University of Georgia)

  • Benjamin B. Parrott

    (University of Georgia
    University of Georgia)

Abstract

Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum lifespan across species has been debated, robust tests of this hypothesis are lacking. Here, we test if epigenetic disorder at various levels of genomic resolution explains maximum lifespan across four mammal species. We show that epigenetic disorder increases with age in all species and at all levels of genomic resolution tested. The rate of disorder accumulation occurs faster in shorter lived species and corresponds to species adjusted maximum lifespan. While the density of cytosine-phosphate-guanine dinucleotides (“CpGs”) is negatively associated with the rate of age-associated disorder accumulation, it does not fully explain differences across species. Our findings support the hypothesis that the rate of epigenetic drift explains maximum lifespan and provide partial support for the hypothesis that CpG density buffers against epigenetic drift.

Suggested Citation

  • Emily M. Bertucci-Richter & Benjamin B. Parrott, 2023. "The rate of epigenetic drift scales with maximum lifespan across mammals," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43417-6
    DOI: 10.1038/s41467-023-43417-6
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    1. Owen R. Jones & Alexander Scheuerlein & Roberto Salguero-Gómez & Carlo Giovanni Camarda & Ralf Schaible & Brenda B. Casper & Johan P. Dahlgren & Johan Ehrlén & María B. García & Eric S. Menges & Pedro, 2014. "Diversity of ageing across the tree of life," Nature, Nature, vol. 505(7482), pages 169-173, January.
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    Cited by:

    1. Steve Horvath & Joshua Zhang & Amin Haghani & Ake T. Lu & Zhe Fei, 2024. "Fundamental equations linking methylation dynamics to maximum lifespan in mammals," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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